Prostate Cancer

Patients treated for prostate cancer by radical prostatectomy

Visceral adipose tissue specimen

Urology CHRU-TOURS

University Hospital

Uniersity Hospital

Structural Network on Prostate Cancer in the French Greater West Region

Réseau Structurant Sur le Cancer de la Prostate du Grand Ouest

Past dietary intake of essential fatty acids is quantified by measuring their concentration in white adipose tissue

Exposure to persistant organic pollutants (organochlorine chemicals, which are fat-soluble) is quantified by measuring the concentration in white adipose tissue

University Hospital, Tours

Institut National de la Santé Et de la Recherche Médicale, France

Nantes University Hospital

Rennes University Hospital

University Hospital, Angers

Poitiers University Hospital

Centre Hospitalier Universitaire de Pointe-a-Pitre

Participants will eat fatty fish and avoiding nuts)

Participants who will avoid both fatty fish and nuts

Obesity

Metabolic Syndrome

Diabetes

At inclusion demographic information recorded, including length of breastfeeding for women. Thereafter, participants will start with a run-in period of two weeks where they will be asked not to consume salmon, mackerel, sardines or other fatty fish or nuts providing a dietary baseline. At baseline, subjects will be randomized to a fish, nuts or control group. The fish group will be asked to consume three to four portions weekly. The fish will be eaten at the main meal and in sandwiches for a total of 600 grams weekly for 6 months. This group will avoid eating nuts. The nut group will consume equal amount of energy (~1400 kcal ) for weekly use for 6 months. This group will avoid eating fatty fish. The control group will consume their usual diet, but asked to avoid fatty fish and nuts.

The fatty fish group

At baseline (conditions for baseline are the same in all three groups) the nut group will consume equal amount of energy (~1400 kcal ~100 grams walnuts, ~50 grams hazelnuts and ~50 grams almonds/week).The nuts will be provided free of charge for the six months. This group will avoid eating fatty fish.

The nut group

After the baseline the control group will consume their usual diet, asked to avoid fatty fish and nuts.

The control group

Oslo University Hospital, Ullevål

Fish or Nuts? Dietary Effects on Cardiometabolic Risk Factors and Persistent Organic Pollutants

Measuring of persistent organic pollutants' levels before and after intervention.
Blood tests will be obtained at randomization, and six months of follow-up for analysis analysis of environmental pollutants including 21 POPs in g/mol .Six-month follow-up samples will be stored for future analyses.

waist circumference in cm as cardiometabolic risk factor

Secondary endpoints will include C-reactive protein

The HOMA index (The homeostatic model assessment (HOMA) is a method used to quantify insulin resistance and beta-cell function) in % will be calculated

HDL-C (high-density lipoprotein) in mmol/L

Sasa Dusanov

PhD candidate

Oslo University Hospital

Insulin Resistance

buphenyl, 7.5 gm/day for two weeks for two studies, one with saline and one admission with intralipid and heparin

biphenyl/offita

Structural Network on Prostate Cancer in the French Greater West Region

Fish or Nuts? Dietary Effects on Cardiometabolic Risk Factors and Persistent Organic Pollutants

Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum