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Reprint of "EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates".

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Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (inter-species) retrospective analysis for drug-induced

[Cyclospora in 2 Mexican children].

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We report two patients, one symptomatic and another asymptomatic, infected with Cyclospora an enteropathogen recently described. The symptoms were: abdominal pain, hiporexia, vomit, bruxism, watery diarrhea 3 or 4 times in a day but self-limiting after 24 to 72 hours. In both children there were

Evaluation of flurazepam and placebo on sleep disorders in childhood.

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The clinically observed results in 40 patients, from 1 to 15 years old, presenting sleep disturbances, in a comparative and statistically approached study of flurazepam 15mg daily against placebo, are reported. Placebo was administered, followed by the drug, during 14 days each. The chief complaints

Continuous-access phencyclidine self-administration by rhesus monkeys leading to physical dependence.

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IV phencyclidine (PCP) self-administration was studied in five rhesus monkeys. The animals were given 23 h per day access with each respose producing an injection. For the first seven sessions saline was made contingent on responding. For the next 30 sessions responses produced 0.01 mg/kg PCP and

Short-Term Side Effects of Low Dose Valproate Monotherapy in Epileptic Children: A Prospective Study.

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Considering the common use of valproate among children, we investigated the short-term side-effects of low dose valproate monotherapy in epileptic children.In this prospective study, 209 epileptic children (48.3% male, mean age: 7.02 ± 3.13 yr) on low

A review of the acute subjective effects of MDMA/ecstasy.

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OBJECTIVE Although several relatively recent reviews have summarized the neuropsychiatric effects associated with chronic ecstasy use, there is no published comprehensive review of studies on the acute subjective effects (ASEs) of MDMA/ecstasy. METHODS The present study reviewed the prevalence,

Do pre-school episodic syndromes predict migraine in primary school children? A retrospective cohort study on health care data.

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Objective To assess the relative risk, predictive value and population attributable risk fraction of pre-school episodic syndromes for later migraine in primary school age children. Methods This retrospective cohort study used health insurance data on 55,035 children born in 2006 with no diagnosis

EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates.

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Herbal & Natural Medicine

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