carcinoid tumor/nikótín

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Associations of tobacco and alcohol use with risk of neuroendocrine tumors of the small intestine in Utah.

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Incidence of small intestine neuroendocrine tumors (SINT) has been increasing in the United States over the past 40 years, with higher incidence in Utah than elsewhere. As information about how these tumors arise is limited, elucidating lifestyle factors associated with SINT in a

Effects of endogenous and tobacco-related amines and nitrosamines on cell growth and morphology of a cell line derived from a human neuroendocrine lung cancer.

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This report is part of a comprehensive research programme to elucidate the role of physiological functions and pathways of pulmonary neuroendocrine cells in the cascade of events that lead to the development of neuroendocrine lung cancer. In this study, a well differentiated neuroendocrine cell line

Carbon dioxide potentiates the mitogenic effects of nicotine and its carcinogenic derivative, NNK, in normal and neoplastic neuroendocrine lung cells via stimulation of autocrine and protein kinase C-dependent mitogenic pathways.

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It has been shown that chronic lung diseases which increase the concentration of pulmonary carbon dioxide (CO2) at the expense of oxygen stimulate the secretion of biogenic amines and neuropeptides by pulmonary neuroendocrine cells (PNE cells) in man and laboratory animals. This increase in

Long-term outcomes and prognostic factors of patients with surgically treated pulmonary atypical carcinoid tumors: our institutional experience with 68 patients.

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UNASSIGNED Pulmonary atypical carcinoid (AC) tumors are rare malignant neoplasms and controversy exists regarding management and prognosis. The purpose of this retrospective study was to describe characteristics, and outcomes of patients treated for pulmonary AC tumors. UNASSIGNED All patients with

[Bronchial carcinoid tumor: study of 60 patients].

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OBJECTIVE To describe the casuistry of bronchial carcinoid tumor in the last 20 years in our hospital and determine survival after surgical treatment. METHODS We retrospectively reviewed the medical records from January 1992 to June 2012 of patients diagnosed with carcinoid tumor by the pulmonary

Is Close Surveillance Indicated for Indolent Cancers? The Carcinoid Story.

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The objective of this article is to determine the relevance of close postresection surveillance for bronchopulmonary carcinoid. From 2006 to 2013, 57 patients underwent lung resection for bronchopulmonary carcinoid. They were assessed for effects of clinical presentation, subtype, stage, and tobacco

Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine--a pooled analysis of over 500,000 subjects in the Asia Cohort Consortium.

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BACKGROUND The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States. METHODS We harmonized the data across 12 cohort studies from mainland China, Japan,

Primary Pulmonary Carcinoid Tumor: A Long-term Single Institution Experience.

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OBJECTIVE Primary carcinoid tumors of the lung are rare tumors which comprise approximately 0.5% to 5% of all lung malignancies in adults and roughly 20% to 30% of all carcinoid tumors. The purpose of this retrospective, descriptive study was to describe the incidence, characteristics, and outcomes

Management of hepatic metastasis of gastrointestinal carcinoid tumors.

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BACKGROUND Hepatic resection, radiofrequency ablation, intra-arterial radiation therapy, and chemoembolization are all potential therapies in the treatment of metastatic carcinoid tumors of the liver. The aim of this study was to determine the prognostic factors in the management of hepatic

The importance of smoking and medical history for development of small bowel carcinoid tumor: a European population-based case-control study.

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OBJECTIVE Little is known about the etiology of small bowel carcinoid tumor (SBC), but a few studies have pointed to certain medical and lifestyle factors as potential risk factors. This study aims to evaluate these findings and to identify new associations. METHODS A population-based European

Early and Late Outcomes of Surgical Treatment in Carcinoid Heart Disease.

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BACKGROUND Symptoms and survival of patients with carcinoid syndrome have improved, but development of carcinoid heart disease (CaHD) continues to decrease survival. OBJECTIVE This study aimed to analyze patient outcomes after valve surgery for CaHD during a 27-year period at 1 institution to

The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features.

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Lung carcinoids (LCs) are rare tumors that comprise 1-5% of lung malignancies but represent 20-30% of neuroendocrine tumors. Their incidence is progressively increasing and a better characterization of these tumors is required. Alterations in somatostatin (SST)/cortistatin (CORT) and ghrelin systems

Environmental tobacco smoke exposure in women with lung cancer.

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BACKGROUND Investigations on environmental tobacco smoke (ETS) exposure that include source intensity, childhood exposure, and association with histologic subtypes among never smoking lung cancer cases are limited. We report the patterns of ETS exposure history in a clinical cohort of women with

Somatic mutations of the protein kinase gene family in human lung cancer.

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Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. We screened the coding sequences of 518 protein kinases (approximately 1.3 Mb of DNA per sample) for somatic mutations in 26 primary lung neoplasms and seven

Poorly differentiated neuroendocrine carcinoma of unknown primary site. A newly recognized clinicopathologic entity.

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Twenty-nine patients with poorly differentiated neuroendocrine tumors of unknown primary site were seen at Vanderbilt Medical Center between May 1977 and February 1987. All patients had pathologic findings typical of neuroendocrine tumors by electron microscopy (22 patients), light microscopy (6

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