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carnosine/heilablóðfall
Krækjan er vistuð á klemmuspjaldið
Bls 1 frá 32 niðurstöður
Comparative Cerebroprotective Potential of d- and l-Carnosine Following Ischemic Stroke in Mice.
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l-carnosine is an attractive therapeutic agent for acute ischemic stroke based on its robust preclinical cerebroprotective properties and wide therapeutic time window. However, large doses are needed for efficacy because carnosine is rapidly degraded in serum by carnosinases. The need for large
Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effect.
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Carnosine, a specific constituent of excitable tissues of vertebrates, exhibits a significant antioxidant protecting effect on the brain damaged by ischemic-reperfusion injury when it was administered to the animals before ischemic episode. In this study, the therapeutic effect of carnosine was
[Protective properties of L-carnosine studied in vitro on a hemorrhagic stroke model].
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The protective properties of L-carnosine have been studied in vitro on a model of hemorrhagic stroke developed on survival olfactory cortex slices of hypertensive rats after long-term exposure to autoblood. The preliminary application of L-carnosine in a concentration of 5 mg/ml regenerates an
Neuroprotective properties of l-carnosine in the brain slices exposed to autoblood in the hemorrhagic stroke model in vitro.
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Neuroprotective properties of L-carnosine have been studied in our in vitro model on olfactory cortex slices of hypertensive rats under a long autoblood (blood clot) influence. Application of L-carnosine (5 mg/ml) on slices before autoblood influence leads to restoration of the activity of
Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke.
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Carnosine is a naturally occurring pleotropic dipeptide which influences multiple deleterious mechanisms that are activated during stroke. Numerous published studies have reported that carnosine has robust efficacy in ischemic stroke models. To further evaluate these data, we have conducted a
Safety and efficacy evaluation of carnosine, an endogenous neuroprotective agent for ischemic stroke.
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OBJECTIVE
An urgent need exists to develop therapies for stroke that have high efficacy, long therapeutic time windows, and acceptable toxicity. We undertook preclinical investigations of a novel therapeutic approach involving supplementation with carnosine, an endogenous pleiotropic
LRP-1 functionalized polymersomes enhance the efficacy of carnosine in experimental stroke.
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Stroke is one of the commonest causes of death with limited treatment options. L-Carnosine has shown great promise as a neuroprotective agent in experimental stroke, but translation to the clinic is impeded by the large doses needed. We developed and evaluated the therapeutic potential of a novel
Functional Performance of L-Carnosine ( -Alanyl-L-Histidine) and Related Imidazole-Containing Dipeptides. Design and Modern Applications of Drug Delivery Systems (Nanosuspensions of Nanosize Materials, Mucoadhesive Drug Delivery Systems, Formulations of Transdermal Patches for Controlled Drug Delivery) Leads to Functional Recovery in Ischemic Stroke.
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Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia.
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Carnosine (beta-alanyl-L-histidine) has been shown to exhibit neuroprotection in rodent models of cerebral ischemia. In the present study, we further characterized the effects of carnosine treatment in a mouse model of permanent focal cerebral ischemia and compared them with its related peptides
Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats.
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Inflammation has a role in the cerebral injury induced by ischemia and the present study aimed to determine the mechanism of the protective effect of beef decoction (BD) with carnosine against it. A rat model of permanent middle cerebral artery occlusion was established using a suture method in the
Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine.
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Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal lobes of both hemispheres was by 36% higher than in other cortical areas,
Influence of carnosine on the cardiotoxicity of doxorubicin in rabbits.
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The aim of this study was to establish the effect of naturally occurring antioxidant carnosine (CAR) on the doxorubicin (DOX)-induced cardiotoxicity in a rabbit model. For this purpose, we evaluated the influence of DOX administration alone and in a combined therapy with CAR on the hemodynamic
[Antioxidant therapy in ischemic stroke].
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The paper presents the results of investigation of emoxipin, an antioxidant synthetic drug, for treatment of patients with ischemic disorders of cerebral circulation. The drug produced a beneficial clinical effect in patients with lacunar and cardioembolic strokes of moderate severity. Therapy with
Neuroprotective actions of a histidine analogue in models of ischemic stroke.
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Histidine is a naturally occurring amino acid with antioxidant properties, which is present in low amounts in tissues throughout the body. We recently synthesized and characterized histidine analogues related to the natural dipeptide carnosine, which selectively scavenge the toxic lipid peroxidation
Carnosine suppresses oxygen-glucose deprivation/recovery-induced proliferation and migration of reactive astrocytes of rats in vitro.
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Glial scar formation resulted from excessive astrogliosis limits axonal regeneration and impairs recovery of function, thus an intervention to ameliorate excessive astrogliosis is crucial for the recovery of neurological function after cerebral ischemia. In this study we investigated the effects of
Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum
- Virkar á 55 tungumálum
- Jurtalækningar studdir af vísindum
- Jurtaviðurkenning eftir ímynd
- Gagnvirkt GPS kort - merktu jurtir á staðsetningu (kemur fljótlega)
- Lestu vísindarit sem tengjast leit þinni
- Leitaðu að lækningajurtum eftir áhrifum þeirra
- Skipuleggðu áhugamál þitt og vertu vakandi með fréttarannsóknum, klínískum rannsóknum og einkaleyfum
Sláðu inn einkenni eða sjúkdóm og lestu um jurtir sem gætu hjálpað, sláðu jurt og sjáðu sjúkdóma og einkenni sem hún er notuð við.
* Allar upplýsingar eru byggðar á birtum vísindarannsóknum
