cinchonidine/cinchona

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Nitrogen photochemistry. V. A new photochemical reduction of the cinchona alkaloids, quinine, quinidine, cinchonidine, cinchonine.

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HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations.

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We report a sensitive method for the estimation of quinine (Qn), cinchonine (Cn), and cinchonidine (Cnd) and a new method based on fluorescence enhancement and detection and quantification of quinidine (Qnd) from Cinchona stem bark and its formulations, using HPTLC. Standard solutions of Qn, Qnd,

Bioproduction of Cinchona alkaloids by the endophytic fungus Diaporthe sp. associated with Cinchona ledgeriana.

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We report that an endophytic filamentous fungus species of the genus Diaporthe isolated from Cinchona ledgeriana (Rubiaceae) produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) upon cultivation in a synthetic liquid medium. This study provides evidence that Cinchona

Alkaloid Production by Transformed Root Cultures of Cinchona ledgeriana.

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Transformed root cultures of CINCHONA LEDGERIANA have been generated by infecting shoots cultured IN VITRO with AGROBACTERIUM RHIZOGENES LBA9402. These root cultures grow axenically in the absence of antibiotics or exogenous plant growth regulators in media containing Gamborg B5 salts at half or

Cinchona alkaloids are also produced by an endophytic filamentous fungus living in cinchona plant.

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We report that the endophytic filamentous fungus Diaporthe sp., isolated from Cinchona ledgeriana and cultivated in a synthetic liquid medium, produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine). This shows that Cinchona alkaloids are produced not only in Cinchona plant

Toxicity of quinoline alkaloids to cultured Cinchona ledgeriana cells.

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The toxicity of Cinchona alkaloids to cell cultures of C. ledgeriana has been studied in relation to alkaloid uptake and possibilities for selecting high-yielding cell lines. The most toxic, quinine, was completely toxic at 5.5 mM. Both quinine and quinidine were more toxic than their unmethoxylated

Effect of Precursors on Growth and Alkaloid Production in Chinchona ledgeriana Leaf-Shoot Organ Cultures.

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The alkaloid contents of the serially propagated CINCHONA LEDGERIANA leaf-shoot organ cultures that were fed with various precursors, were compared to the control cultures that were grown in Murashige and Skoog's medium supplemented with 5 mg/l benzyladenine. the average total alkaloid content of

Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.

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The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide

Rapid and green analytical method for the determination of quinoline alkaloids from Cinchona succirubra based on Microwave-Integrated Extraction and Leaching (MIEL) prior to high performance liquid chromatography.

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Quinas contains several compounds, such as quinoline alkaloids, principally quinine, quinidine, cinchonine and cichonidine. Identified from barks of Cinchona, quinine is still commonly used to treat human malaria. Microwave-Integrated Extraction and Leaching (MIEL) is proposed for the extraction of

Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow Cinchona Bark (Rubiaceae: Cinchona calisaya).

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Considerable inter- and intraspecific variation with respect to the quantity and composition of plant natural products exists. The processes that drive this variation remain largely unknown. Understanding which factors determine chemical diversity has the potential to shed light on plant defenses

Evaluation of antibacterial and anti-biofilm activities of cinchona alkaloid derivatives against Staphylococcus aureus.

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Bacterial biofilms are resistant to most of the commonly available antibacterial chemotherapies. Thus, an enormous need exists to meet the demands of effective anti-biofilm therapy. In this study, a small library of cinchona alkaloids, including the naturally occurring compounds cinchonidine and

Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.

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The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and in vivo against Plasmodium falciparum malaria parasites. They may act by the inhibition of heme

Cinchona Alkaloids-Derivatives and Applications.

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Major Cinchona alkaloids quinine, quinidine, cinchonine, and cinchonidine are available chiral natural compounds (chiral pool). Unlike many other natural products, these alkaloids are available in multiple diastereomeric forms which are separated on an industrial scale. The introduction discusses in

Competitive chemisorption between pairs of cinchona alkaloids and related compounds from solution onto platinum surfaces.

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Quinoline-derived compounds exhibit the following relative chemisorption strengths from CCl4 solutions onto platinum surfaces, as determined by in-situ infrared spectroscopy: quinine, quinidine > cinchonidine > cinchonine > 6-methoxyquinoline > lepidine > quinoline. This sequence explains nonlinear

Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.

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The 2-oxidation activity on the pyrimidine ring of RS-8359, a MAO-A inhibitor, is the major metabolic pathway catalysed by aldehyde oxidase. This study investigated the species differences in the 2-oxidation activity by using liver cytosolic fractions from rats, mice, guinea-pigs, rabbits, dogs,

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