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coronary vasospasm/kalín
Krækjan er vistuð á klemmuspjaldið
Bls 1 frá 38 niðurstöður
Coronary artery spasm in intact dogs induced by potassium and serotonin.
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Although coronary artery spasm has been implicated as an important cause of myocardial ischemia in humans, an animal model of reversible segmental coronary constriction has not been described. To provoke coronary spasm in open-chest dogs, selected vasoconstricting agents adsorbed to viscous ion
Decreasing potassium conductance--a possible mechanism of phasic coronary vasospasm.
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Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process.
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In the vasculature, ATP-sensitive potassium channels (KATP) channels regulate vascular tone. Mice with targeted gene disruptions of KATP subunits expressed in vascular smooth muscle develop spontaneous coronary vascular spasm and sudden death. From these models, it was hypothesized that the loss of
The role of the endothelium on calcium-entry blockade in coronary vasospasm.
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Calcium-entry blockers are widely used for the treatment of coronary vasospasm. The mechanisms responsible for coronary vasospasm are still uncertain, but ultimately involve contraction of the vascular smooth muscle of the large coronary artery. The direct constrictor responses of coronary smooth
[Evaluation of the effectiveness and safety in the use of cold-diltiazem-potassium cardioplegia in coronary artery bypass surgery: a first clinical trial].
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The effectiveness and safety of diltiazem (DIL), a slow channel calcium blocker, added in cold potassium cardioplegic (CP) solution was evaluated in coronary artery bypass graft (CABG) surgery for 2 purposes; (1) protection of ischemic myocardium during cardiac arrest and (2) prevention of
Thyrotoxicosis and coronary artery spasm: case report and review of the literature.
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A 51-year old Middle-Eastern man presented with recurrent chest pain associated with ST-segment elevation. The patient was treated with placement of a stent in the right coronary artery. He was subsequently diagnosed with severe hyperthyroidism secondary to Graves disease, which is thought to be the
Effects of vasoconstrictors on isolated rabbit coronary arteries exposed to isotonic iohexol. Potassium chloride-, histamine-, endothelin-, and prostaglandin-F2 alpha-induced contractions on arteries exposed to iohexol without and with osmotic additions (sodium chloride or glucose).
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OBJECTIVE
A major effect of contrast media (CM) on coronary vessels is vasodilatation, but occasionally, both ionic and nonionic media may cause coronary artery spasm. The influence of CM on the actions of vasoactive substances is not well known. To investigate the effects on rabbit coronary
Inhibitory effects of nisoldipine on serotonin and potassium induced contractions of porcine coronary and femoral arteries.
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The inhibitory effect of nisoldipine (Baymycard, Syscor; CAS 63675-72-9) and nifedipine on the serotonin and potassium induced contractions of porcine coronary and femoral arteries in vitro has been investigated. Both nisoldipine and nifedipine inhibited preferentially the serotonin induced
High potassium concentration in a parenteral preparation of glyceryl trinitrate. Need for caution if given by intracoronary injection.
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Glyceryl trinitrate (Tridil) was given by intracoronary injection to a patient who developed coronary artery spasm during angioplasty. Transient exacerbation of chest pain and electrocardiographic changes occurred. This formulation of the drug contains a high concentration of potassium ions and
Effects of the new potassium channel opener JTV-506 on coronary vessels in vitro and in vivo.
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The vascular effects of JTV-506 ((-)-(3S,4R)-2.2-bis(methoxymethyl)- 4-[(1,6-dihydro-l-methyl-6-oxo-3-pyridazinyl)amino]-3-hydroxychroman+ ++-6- carbonitrile hemihydrate, CAS 170148-29-5), a new potassium channel opener, was evaluated in isolated coronary arteries and anesthetized dogs. JTV-506 (1
Intracoronary nicorandil relieves multiple coronary vasospasm with hemodynamic collapse.
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A 49-year-old woman was referred to hospital because of chest discomfort. Coronary angiography revealed subtotal occlusion of the left coronary artery and the right coronary artery, but subsequent hemodynamic collapse occurred. Based on the results of intravascular ultrasound the occlusion was
The Novel Inodilator ORM-3819 Relaxes Isolated Porcine Coronary Arteries: Role of Voltage-Gated Potassium Channel Activation.
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Relaxation and changes in the transmembrane potential of vascular smooth muscle induced by ORM-3819, a novel inodilating compound, were investigated in isolated porcine coronary arteries. Isometric tone was studied on arterial rings precontracted by KCl (30 mM), and resting membrane potential was
Phasic contractions of canine and human coronary arteries induced by potassium channel blockers.
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To gain insight into mechanisms underlying phasic coronary vasospasm in patients with variant angina pectoris, we studied whether phasic contractions could be induced in isolated canine and human coronary arteries by agents which block potassium channels. Phasic contractions of canine coronary
Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain.
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Large conductance, calcium- and voltage-gated potassium (BK) channels regulate various physiological processes and represent an attractive target for drug discovery. Numerous BK channel activators are available. However, these agents usually interact with the ubiquitously distributed channel-forming
Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress.
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Adenosine triphosphate-sensitive potassium (K(ATP)) channels are thought to mediate the stress response by sensing intracellular ATP concentration. Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2). We studied the response
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