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In vitro and in silico evaluation of NF-κB targeted costunolide action on estrogen receptor-negative breast cancer cells--a comparison with normal breast cells.

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Costunolide, a sesquiterpene lactone is a plant-derived secondary metabolite found to be present in most of the pharmacologically active herbs, being the cause for their medicinal values. The present study aims to evaluate the cytotoxic effect of costunolide isolated from Costus speciosus rhizome

In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer.

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OBJECTIVE The goal of this study was to evaluate the antioxidant and antiproliferative activities of 10 traditional medicinal plants, Asclepias curassavica, Ophiorrhiza mungos Linn., Cynodon dactylon (L.) Pers, Costus speciosus (J. Koenig.) Smith Costaceae, Achyranthes aspera L., Amaranthus tristis

Cytotoxic Impact of Costunolide Isolated from Costus speciosus on Breast Cancer via Differential Regulation of Cell Cycle-An In-vitro and In-silico Approach.

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Costunolide, a sesquiterpene lactone, is a biologically active molecule found in most of the medicinally valuable plants. The present study aims to evaluate the anticancer property of costunolide isolated from Costus speciosus against breast cancer cell lines (MCF-7 and MDA-MB-231). Costunolide

Targeting prostate cancer cell proliferation, stemness and metastatic potential using Costus speciosus derived phytochemicals.

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Prostate cancer is still at the forefront causes of cancer-related morbidity and mortality in men throughout the globe. The disease is initiated and fostered by a subset of cancer stem cells (CSCs). Costus speciosus is an oriental herb used in traditional medicine and is a source of bioactive

Biogenic green synthesis of MgO nanoparticles using Saussurea costus biomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials

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Distinct morphological MgO nanoparticles (MgONPs) were synthesized using biomasses of Saussurea costus roots. The biomass of two varieties of Saussurea costus (Qustal hindi and Qustal bahri) were used in the green synthesis of MgONPs. The physical and chemical features of nanoparticles were

[Skin sensitization of costus root oil and peripheral lymphocyte count in gastric and colon cancers].

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Costus root oil is a new primary sensitizer to examine the delayed, cell-mediated immune system. The peripheral blood lymphocyte count has been measured in 68 cases of carcinoma of the stomach and colon. The count has been correlated with the stage of tumor spread and the patient's delayed

[Costus root oil test in cancer patients; correlation with tumor stage].

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Delayed hypersensitivity skin responses to costus root oil were measured in patients with colon, stomach, breast and lung cancer and in healthy controls. Cancer patients were staged according to tumor spread. Differences were demonstrated between cancer patients and controls. Patients with localized

[Effect of costus root oil in murine tumors].

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Costus root oil is a new primary sensitizer for examination of the delayed cell-mediated immune system. Histologic findings of skin producing a positive reaction to costus root oil show accumulation of lymphoid cells. If the delayed hypersensitivity reaction caused by costus root oil were to be used

[Cutaneous delayed hypersensitivity to costus root oil in lung cancer].

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Costus root oil is a new primary sensitizer for examining the delayed, cell-mediated immune system. Ninety-nine patients with lung cancer were tested for skin reactions to costus root oil. The incidence of positive reactions to costus root oil decreased with the progress of lung cancer. The

Secondary Metabolites of Saussurea costus Leaf Extract Induce Apoptosis in Breast, Liver, and Colon Cancer Cells by Caspase-3-Dependent Intrinsic Pathway

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Background: Apoptosis, a major form of programmed cell death, plays a vital role in regulating tissue development and maintenance of homeostasis in eukaryotes. Apoptosis can occur via a death receptor-dependent extrinsic or a

Insulin Plant (Costus pictus) Extract Restores Thyroid Hormone Levels in Experimental Hypothyroidism.

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BACKGROUND The aim of the present study was to investigate the preventive effect of Costus pictus leaf extract in experimental hypothyroidism. METHODS Forty male Wistar rats were randomly divided into four groups with ten rats in each group: Control (C), hypothyroid (H), control+extract (C+E), and

Antimicrobial, antiquorum sensing, and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes.

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The quorum sensing inhibitory (QSI) and antimicrobial potentials of the total methanol extract (TME) and different extractives as well as the sesquiterpenes: dehydrodihydrocostus lactone (1), dehydrocostus lactone (2), arbusculin A (3), santamarine (4), reynosin (5), and specioic acid (6) isolated

Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia.

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BACKGROUND Endophytes, microorganisms which reside in plant tissues, have potential in producing novel metabolites for exploitation in medicine. Cytotoxic and antibacterial activities of a total of 300 endophytic fungi were investigated. METHODS Endophytic fungi were isolated from various parts of

Costunolide inhibits proinflammatory cytokines and iNOS in activated murine BV2 microglia.

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Costunolide, a sesquiterpene lactone present in Costus speciosus root exerts a variety of pharmacological activity but its effects on neuroinflammation have not been studied. Microglia, the resident phagocytic cells in the central nervous system respond to neuroinflammation and their overwhelming

Pharmacological studies on the efficacy of a thymoquinone-containing novel polyherbal formulation against cisplatin-induced hepatorenal toxicity in rats.

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The aim of this study was to investigate the protective effect of a novel polyherbal formulation against cisplatin-induced hepatorenal toxicity in six groups of rats. Group I: Normal control; Group II: cisplatin (5 mg/kg i.p.); Group III: cisplatin (5 mg/kg i.p.) + cystone (750 mg/kg p.o.); Group

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