Constipation

Inflammation

Tungs' Taichung MetroHarbour Hospital

Constipation, Gut Microbiome, and Microbial-derived Uremic Toxins From the Gut Microbiota in HD Patients

Constipation, Gut Microbiome, and Microbial-derived Uremic Toxins From the Gut Microbiota in HD Patients Is There a Relationship Between Them ?

gut microbiota composition have been associated with increased production of indoxyl sulfate and p-cresyl sulfate, which is directly associated with endothelial dysfunction, inflammation and oxidative stress, and increases in the incidence of CVD and mortality.

16S rDNA Illumina amplicon profiles of faecal samples to assess potential associations between microbiota composition and constipation.

Tungs’ Taichung Metroharbour Hospital

Sarcopenia

Mitochondrial DNA

Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates

Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates in Taiwanese Hemodialysis Patients

The copy number of the mtDNA and the nDNA is calculated using the threshold cycle number (Ct) and intrapolating from the standard curve. The ratio of the copy number of mtDNA to the copy number of nDNA is measurement of mtDNA content.

ndoxyl sulfate (IS) and para-cresol (p-cresol) belong to the group of protein-bound uremic toxins that are poorly cleared by dialysis and are associated with poor clinical outcomes.the group of protein-bound uremic toxins that are poorly cleared by dialysis and are associated with poor clinical outcomes.

Total 8-iso-PGF2-alpha concentrations in plasma were measured by a specific enzyme immunoassay (EIA) kit

The IL-6 was determined from serum samples and controls using standardized enzymelinked immunosorbent assay (ELISA) methods

The TNF-α was determined from serum samples and controls using standardized enzymelinked immunosorbent assay (ELISA) methods

The LBP was determined from serum samples and controls using standardized enzymelinked immunosorbent assay (ELISA) methods

the fractions of HMA, HNA-1, and HNA-2 to total HSA were measured using HPLC

Roles of Uremic Toxins in Uremic Sacropenia

Association of Uremic Toxins and Sacropenia in Hemodialysis Patients

To evaluate the association of sacropenia defined according to 1. Low muscle mass 2. Low muscle strength 3. Low physical performance and serum levels of some uremic toxins such as indoxyl sulfate, p-cresol and hippuric acid will be measured.

cresol/dichloromethane

Constipation, Gut Microbiome, and Microbial-derived Uremic Toxins From the Gut Microbiota in HD Patients

Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates

Roles of Uremic Toxins in Uremic Sacropenia

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