epiretinal membrane/tyrosine

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Neurotrophic factor receptors in epiretinal membranes after human diabetic retinopathy.

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OBJECTIVE Formation of epiretinal membranes (ERMs) in the posterior fundus results in progressive deterioration of vision. ERMs have been associated with numerous clinical conditions, including proliferative diabetic retinopathy (PDR), but its pathogenic mechanisms are still unknown. This study was

High-Mobility Group Box-1 Modulates the Expression of Inflammatory and Angiogenic Signaling Pathways in Diabetic Retina.

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OBJECTIVE The expression of high-mobility group box-1 (HMGB1) is upregulated in epiretinal membranes and vitreous fluid from patients with proliferative diabetic retinopathy and in the diabetic retina. HMGB1 mediates inflammation, breakdown of the blood-retinal barrier and apoptosis in the diabetic

The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes.

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To test the hypothesis that increased expression of proinflammatory cytokine high-mobility group box-1 (HMGB1) in epiretinal membranes and vitreous fluid from patients with proliferative diabetic retinopathy and in retinas of diabetic rats plays a pathogenetic role in mediating diabetes-induced

Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy.

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OBJECTIVE To determine whether hepatocyte growth factor (HGF) receptor (HGFR) is expressed in retinal pigment epithelial (RPE) cells and to test whether RPE cells are responsive to HGF. To evaluate expression of HGFR in human donor eyes and in several epiretinal membranes associated with

HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR.

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OBJECTIVE To understand molecular events that lead to retinal pigment epithelial (RPE) cell proliferation and migration during the early phases of proliferative vitreoretinopathy (PVR) in a rabbit model. METHODS Retinal holes were created and interleukin-1beta(IL-1beta) was injected intravitreally.

Dasatinib affects focal adhesion and myosin regulation to inhibit matrix contraction by Müller cells.

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Epiretinal membrane (ERM) contraction is associated with a variety of ocular diseases that cause macular dysfunction. Trans-differentiated Müller cells have been identified in ERMs, and have been implicated to be involved in the contractile process. In this study, we tested the effect of dasatinib,

Focal adhesion kinase family is involved in matrix contraction by transdifferentiated Müller cells.

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Transdifferentiated Müller cells that adopt a fibroblastic/myofibroblastic phenotype have been identified in epiretinal membranes (ERMs) in several ocular disorders, and have been implicated to play a role in the formation and/or the contraction of ERMs. We have previously demonstrated that

Amino-acid levels in subretinal and vitreous fluid of patients with retinal detachment.

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OBJECTIVE To compare the concentration of amino acids in subretinal and vitreous fluid of patients with primary rhegmatogenous retinal detachment to that of control vitreous. METHODS This prospective, observational study measured amino-acid levels in subretinal fluid of patients undergoing scleral

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