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Structural parameters governing activity of Pluronic triblock copolymers in hyperthermia cancer therapy.

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OBJECTIVE To identify specific Pluronic triblock copolymer structural properties which are critical to its function as a sensitiser in hyperthermia treatment of experimental colorectal adenocarcinoma. METHODS DHD/K12/TRb rat colorectal adenocarcinoma cells were exposed to Pluronics, a family of

Humoral immune response following extracorporeal immunoadsorption therapy of patients with hypercholesterolemia.

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Low-density lipoprotein apheresis (LDL-apheresis) is an extracorporeal procedure that preferentially removes LDL cholesterol from the blood. One of the primary techniques for performing this procedure uses immunoadsorption columns containing monospecific polyclonal sheep antibodies to human LDL

Infection risk of cardiac catheterization and arterial angiography with single and multiple use disposable catheters.

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In a prospective study from November 1986 to June 1987, a cohort of 414 patients underwent cardiac catheterization or angiography with either multiple use or single use disposable catheters: 161 patients were studied with 426 single use catheters, 152 patients with 384 multiple use catheters which

Pyrogenic reactions after inadvertent infusion of endotoxin during cardiac catheterizations.

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In April 1976 the attack rate of chills and fever with or without falls in blood pressure increased in association with cardiac catheterizations. Fevers were associated with coronary angiography and right and left heart catheterizations. Blood cultures were negative, and reactions did not correlate

Absolute MR thermometry using nanocarriers.

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Accurate time-resolved temperature mapping is crucial for the safe use of hyperthermia-mediated drug delivery. We here propose a magnetic resonance imaging temperature mapping method in which drug delivery systems serve not only to improve tumor targeting, but also as an accurate and absolute

Detection of endotoxin on sterile catheters used for cardiac catheterization.

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Pyrogen reactions during cardiac catheterization are an alarming complication that frightens patients and baffles many physicans. This report describes a simple, reproducible, precise technique for the measurement of endotoxin-like activity on the inner and outer surfaces of catheters intended for

[Infectious mitral endocarditis after radiofrequency catheter ablation of a left lateral accessory pathway].

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A 2-years-old child with Wolff-Parkinson-White syndrome associated with life-threatening symptoms underwent radiofrequency ablation of a left lateral accessory pathway. A deflectable 5F bipolar electrode catheter positioned above the atrioventricular groove by transeptal approach was used for

Preparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles.

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Gold nanorods (GNRs) have the potential to be used as imaging and hyperthermia agents for cancer theranostics. Clinical applications of as-synthesized GNRs (i.e., cetyl trimethylammonium bromide (CTAB)-coated GNRs) are currently limited by their cytotoxicity and insufficient colloidal stability.

A cost effectiveness based safety and efficacy study of resterilized intra-parenchymal catheter based intracranial pressure monitoring in developing world.

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BACKGROUND The management of traumatic brain injury (TBI) aims to maintain the normal cerebral perfusion in spite of the mass lesions that may occur (haematoma, contusion, and oedema). The monitoring of the intracranial pressure (ICP) is a step in that direction. The intra-parenchymal catheters have

Anti-inflammatory polymersomes of redox-responsive polyprodrug amphiphiles with inflammation-triggered indomethacin release characteristics.

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Inflammation serves as a natural defense mechanism to protect living organisms from infectious diseases. Nonsteroidal anti-inflammatory drugs (NSAIDs) can help relieve inflammatory reactions and are clinically used to treat pain, fever, and inflammation, whereas long-term use of NSAIDs may lead to

Design of Smart PEO-PPO-PEO-Magnetic Drug Delivery System for Alzheimer's Diseases Diagnosis and Therapy.

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Amyloid-β (Aβ) oligomers are more likely to be the pathogenic agents of Alzheimer's disease. Development of multiple approaches in detection and clearance pathway for Aβ, may eventually lead to diagnosis and treatments of AD. Following this concept, we proposed temperature-responsive magnetic drug

Allergic reaction to polysulphone membrane dialyser masquerading as infection.

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Hypersensitivity reactions during haemodialysis are well documented in the literature. Most dialysis membrane reactions occur with ethylene oxide or non-biocompatible membranes and less frequently with biocompatible membranes. The symptoms are non-specific except for the temporal relationship

Highly stable multi-anchored magnetic nanoparticles for optical imaging within biofilms.

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Magnetic nanoparticles are the next tool in medical diagnoses and treatment in many different biomedical applications, including magnetic hyperthermia as alternative treatment for cancer and bacterial infections, as well as the disruption of biofilms. The colloidal stability of the magnetic

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