gestational trophoblastic disease/phosphatase

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Immunohistochemistry in the diagnosis of the gestational trophoblastic disease.

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OBJECTIVE The gestational trophoblastic disease summarizes all types of hydatidiform moles, placental site trophoblastic tumor and choriocarcinoma. It is of clinical relevance to distinguish between complete hydatidiform mole and partial hydatidiform mole to predict prognosis of recurrency of molar

Immunobiology of complete molar pregnancy and gestational trophoblastic tumor.

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The unique curability of gestational trophoblastic tumors may in part be attributable to a host immunologic response. The occurrence of rapidly progressive and fatal choriocarcinoma may be favored by histocompatibility between patients and their partners. However, histocompatibility is not a

[Expression and significance of LMP2 and PPM1A in gestational trophoblastic disease].

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OBJECTIVE To investigate the expression of low molecular mass polypeptide-2 (LMP2) and protein phosphatase 1A (PPM1A) in gestational trophoblastic disease and elucidate their predictive value in malignant transformation of hydatidiform mole. METHODS The expressions of LMP2 and PPM1A protein in 196

Expression of trophoblast-leukocyte common antigens and placental-type alkaline phosphatase in complete molar pregnancy.

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The current study was undertaken to determine the localization of trophoblast-leukocyte common antigens and placental-type alkaline phosphatase in complete molar pregnancy with the use of rabbit antiserum and murine monoclonal antibodies in immunofluorescence assays. Trophoblast-leukocyte common

[Trophoblastic disease. I. Use of immunohistochemistry in the diagnosis of complete hydatidiform moles].

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Immunohistochemical study of 15 complete moles detected expression of human chorion-gonadotropin (hCG), human placental lactogen (hPL) and placental alkaline phosphatase (PLAP). Syncytiotrophoblast showed the most conspicuous expression of hCG, hPL positivity was mild, PLAP positivity poor.

Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.

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Epithelioid trophoblastic tumor (ETT) is a term proposed for an unusual variant of trophoblastic tumor that is closely related to choriocarcinoma but shows monomorphic growth of highly atypical trophoblastic cells instead of the typical dimorphic pattern of choriocarcinoma. We report here 3 cases of

Placental site nodule and characterization of distinctive types of intermediate trophoblast.

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Both placental site nodule and exaggerated placental site are described as being composed of intermediate trophoblast (IT), yet their morphological features and clinical presentation differ significantly. This study was undertaken to evaluate the morphological and immunohistochemical features of

[Clinicopathologic study of tumors of intermediate trophoblasts].

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OBJECTIVE To study the clinicopathologic features and immunophenotype of placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). METHODS During the period from 1959 to 2005, a total of 1012 cases of gestational trophoblastic disease were diagnosed in Beijing Obstetrics

Placental proteins in oncology.

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Many placental proteins appear in the serum and tumours of patients with malignant disease, but few have achieved an established position in clinical management. Chorionic gonadotrophin is a sensitive and effective marker for trophoblastic disease. Gonadal germ cell tumours containing extraembryonic

Choriocarcinoma Presenting as a Pleural Effusion

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Choriocarcinoma is a germ cell tumor characterized by widespread metastases and poorly differentiated cells. Non-gestational choriocarcinoma, or primary choriocarcinoma is a trophoblastic disease which is associated with a poor patient prognosis and is markedly angioinvasive. Primary non-gestational

Selective immunolabeling of early gestational cytotrophoblast and its neoplastic counterpart by the monoclonal antibody Ber-EP4.

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This report presents preliminary observations on the distribution of an epithelial surface antigen in human trophoblastic cells studied with the monoclonal antibody Ber-EP4 by means of an immunoperoxidase technique. Three cases of gestational choriocarcinoma and 20 cases of both villous and

Placental site nodule: a clinicopathologic study of 38 cases.

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This report describes the clinical, histological, and immunohistochemical features of 38 cases of placental site nodule (PSN), a recently described lesion of intermediate trophoblast (IT). The patients ranged in age from 20 to 47 years (mean, 31.1 years). PSNs were diagnosed in endometrial (30

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