great/hyoscine

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Hyoscine vs glycopyrronium for drying respiratory secretions in dying patients.

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The 'death rattle' is a common symptom among dying people, and causes a great deal of anxiety and upset to relatives and carers, including nurses. A mini-review was carried out to evaluate the effectiveness of two drugs--hyoscine hydrobromide and glycopyrronium--in drying up respiratory secretions

Administration of hyoscine- n-butylbromide during colonoscopy: a survey of current UK practice.

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OBJECTIVE Current British Society of Gastroenterology (BSG) guidelines suggest that hyoscine-n-butylbromide (Buscopan) should be avoided during colonoscopy in patients with a history of angle-closure glaucoma. Angle-closure glaucoma, however, is not very common, is asymptomatic before onset and is

The 'induction' dose of thiopentone. A method of study and preliminary illustrative results.

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Study of the minimal dose requirements for induction of anaesthesia poses great problems which are solved by the use of a standard administration technique and the abolition of the eyelash reflex as an endpoint. This has been used in 2206 consecutive unselected inductions, in which variables

Is current UK management of oesophageal food bolus obstruction evidence based? An e-mail survey and literature review.

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There is a great deal of variation in individual management of non-sharp oesophageal food bolus obstruction in the United Kingdom. An e-mail survey of consultants and specialist registrars in ENT was carried out to establish current UK practice. A review of the published literature was under-taken

Reversibility of the analgesic effect of meptazinol in volunteers.

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A double-blind randomized placebo-controlled study was carried out in 8 healthy volunteers to determine whether the analgesic and other actions of meptazinol could be reversed by naloxone or hyoscine. Heart rate, blood pressure, respiratory rate, pupil diameter, forearm ischaemic exercise tolerance

Scopolamine blood levels following buccal versus ingested tablets.

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Speed of absorption and elimination of an antimotion sickness drug sets limits on the protection afforded. The aim of this experiment was to determine whether a well proven antimotion sickness drug--scopolamine (hyoscine)--could be absorbed more rapidly from buccal tablets than from the standard

Preanaesthetic medication: a survey of current usage.

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A survey has been carried out amongst the UK based members of the Association of Anaesthetists of Great Britain and Ireland regarding their practice of premedication. Ninety-three per cent of respondents (reply rate 51.7%) used sedative-hypnotic premedication routinely in adults and 84% in children.

Administration of drugs by infusion pumps in palliative medicine.

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A retrospective study was carried out in 100 adult patients with advanced malignant disease. They were given subcutaneous continuous infusions of medication for symptom relief. The drugs were administered through a butterfly needle inserted subcutaneously in the anterior chest wall using a

Establishing zebrafish as a model to study the anxiolytic effects of scopolamine.

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Scopolamine (hyoscine) is a muscarinic acetylcholine receptor antagonist that has traditionally been used to treat motion sickness in humans. However, studies investigating depressed and bipolar populations have found that scopolamine is also effective at reducing depression and anxiety symptoms.

[A simple method for the measurement of human gastric emptying: standardization of operative parameters].

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The radioisotopic techniques used for the measurement of gastric emptying in man require complex and expensive scintiscanners or gamma-cameras. In this investigation, a simple method utilizing a single and inexpensive detector was evaluated; in addition, the suitability of 99Tcm sulphur colloid as a

Colon distension and scan protocol for CT-colonography: an overview.

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This article reviews two important aspects of CT-colonography, namely colonic distension and scan parameters. Adequate distension should be obtained to visualize the complete colonic lumen and optimal scan parameters should be used to prevent unnecessary radiation burden. For optimal distension,

Raise up of Scopolamine in Hairy Roots Via Agrobacterium rhizogenes ATCC15834 as Compared with Untransformed Roots in Atropa komarovii

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Atropa komarovii generates tropane alkaloids and three other compounds such as hyoscyamine. Racemate atropine and scopolamine (hyoscine) are the main alkaloids with anticholinergic, antispasmodic, and sedative agents. A proficient convention has been reported for the formation

The sites of action of 5-hydroxytryptamine in nerve-muscle preparations from the guinea-pig small intestine and colon.

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1 The sites of action of 5-hydroxytryptamine (5-HT) were examined in isolated segments of guinea-pig intestine. Mechanical records were taken from the longitudinal muscle of the ileum and proximal colon and from the circular muscle of the ileum and distal colon.2 In order to examine direct actions

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