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Participants' expectations of marijuana effects are frequently cited as unmeasured post hoc explanations of variability in response to the drug, or of the data which fail to conform to the experimenters' expectations of the drug's effects. Twenty-four male volunteers, experienced in the use of
The discovery of the endocannabinoid system nearly three decades ago generated great interest among pain scientists. Moreover, its analogy with the opioid system in terms of evolutionary preservation, tissue localization and analgesic activity enabled a vast new field for the development of
Cannabis celebration day, also known as "420 day", takes place at 4:20pm on April 20 every year. The objective of this paper is to study whether there is an increase in road traffic collisions in Great Britain on that day. We used daily car crash data resulting in death or injury from all
The British government downgraded cannabis from a Class B to a Class C drug in 2004; but in 2008 it reversed this decision,and cannabis is due to be reclassified back to Class B in January 2009. In this Harm Reduction Digest, Paul Turnbull assesses the impact of reclassification to Class B focusing
Cannabis plants have been grown in the United Kingdom of Great Britain and Northern Ireland from seeds taken from seizures of cannabis of known geographical origin and chemistry. The gross physical appearance and cannabinoid patterns of many of the cannabis samples produced in the United Kingdom
Women who use psychoactive substances could have higher levels of unplanned pregnancy and of difficulties accessing long-term contraceptive methods than those who do not use these substances. General population data on this topic are rare, particularly in A second generation of Cannabis plants has been grown from seeds produced by first generation plants which were raised in the United Kingdom of Great Britain and Northern Ireland from seeds taken from imported cannabis of known geographical origin and chemistry. The gross physical appearance of the
Two further generations of Cannabis plants have been grown from seeds produced by earlier generation plants which were raised in the United Kingdom of Great Britain and Northern Ireland in 1980 and 1981. The original seedstocks were from known countries of origin. Although there are exceptions, both
Allosteric modulators of cannabinoid receptors hold great therapeutic potential, as they do not possess intrinsic efficacy, but instead enhance or diminish the receptor's response of orthosteric ligands allowing for the tempering of cannabinoid receptor signaling without the desensitization,
A relatively high proportion of young adults in San Francisco have used marijuana one or more times. The proportion in this age group who have used marijuana is as great among nonstudents as among students.
ABSTRACTBackground:Compared to their non-using age peers, older marijuana users are known to have lower marijuana risk perceptions. We examined associations of older marijuana users' risk perceptions with their marijuana use patterns and substance use disorders.
METHODS
Data are from 2013 to 2015
BACKGROUND
Cannabis is one of the most widely used psychoactive substances in the United States (U.S.). Perceived risk of use is associated with substance use; the recent debate surrounding medicalization and legalization of cannabis in the U.S. has the potential to impact perceived risk of use.
We read with great interest the results of the trial of lenabasum in SSc. After many recent failed studies, we are excited to come across a positive drug trial in SSc. However, the systemic manifestations of the subjects i.e. pulmonary manifestations such as PH and ILD deserve a more detailed