hemoglobinopathies/uppköst

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[Stroke in a child due to hemoglobinopathy AS].

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BACKGROUND Falciform cell anaemia is a genetically determined haemoglobinopathy which in homozygote form (HbSS) is accompanied by neurological disorders in a quarter of the patients, mainly in the form of cerebral ischemia. Some authors consider the heterozygote (HbAS) form to be asymptomatic,

Lupus nephritis in a patient with sickle cell disease.

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Introduction. The diagnosis of systemic lupus erythematosus (SLE) in patients with sickle cell disease (SCD) can be difficult to establish because the musculoskeletal, central nervous system, and renal manifestations are similar in both diseases. In the presented case, we highlight the diagnostic

Simultaneous excision of two cerebral abscesses with the capsule.

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METHODS A boy of 8 suffering from hemoglobinopathy M had two encapsulated cerebral abscesses confirmed on CT--one in the right temporal lobe, the second in the left frontal lobe--measuring 48 and 58 mm in diameter respectively. The disease began with fever, daily vomiting, and permanent somnolency,

[Splenic infarction at high altitude, Huaraz-Peru (3,100 masl)].

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We report three cases of splenic infarction in healthy men for the first time that amounted to high altitudes, observed in the hospital "Victor Ramos Guardia" Huaraz (3100 m). Case 1 (1995) of 55 years, born in Cuba, from Lima, caucasian suddenly presented acute abdominal pain in epigastrium,

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

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Exposure of red blood cells to oxidants increases production of methemoglobin (MHb) resulting in impaired oxygen delivery to tissues. There are no reliable estimates of methemoglobinemia in low resource clinical settings. Our objectives were to: i) evaluate risk factors for methemoglobinemia in

[Blackwater fever in adults with sickle cell anemia. Two fatal cases].

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Blackwater fever is characterized by severe intravascular hemolysis with renal failure caused by recurrent use of quinine for prophylaxis. Once described in European patients, sporadic cases have been reported more and more often in autochthonous Africans and Asians. Newer antimalarials including

Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors.

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Butyrates have been studied as cancer differentiation agents in vitro and as a treatment for hemoglobinopathies. Tributyrin, a triglyceride with butyrate molecules esterified at the 1, 2, and 3 positions, induces differentiation and/or growth inhibition of a number of cell lines in vitro. When given

Pandemic influenza A (H1N1) 2009: risk factors for hospitalization.

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OBJECTIVE To evaluate pandemic influenza A (H1N1) 2009 in hospitalized patients in order to identify risk factors for hospitalization and, consequently, for the worsening of the disease. METHODS This retrospective observational study was conducted between March and December of 2010. The data were

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