karwinskia humboldtiana/atrophy

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Rhamnus cathartica (buckthorn) hepatocellular toxicity in mice.

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The toxicity of the plant Rhamnus cathartica was assessed in mice after the plant was identified as a potential cause of an idiopathic neurologic disease in horses. Another member of the Rhamnaceae family, Karwinskia humboldtiana, is neurotoxic to mammals and birds and can induce hepatic

Renal failure during acute toxicity produced by tullidora ingestion (Karwinskia humboldtiana).

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1. Acute effects of Karwinskia humboldtiana (Kh) were studied in some renal functions and structural patterns of renal tissue. 2. Haemodynamic changes were observed with decrements of the glomerular filtration rate, renal plasma flow and filtration fraction during acute intoxication. 3. A marked

Experimental intoxication with fruit and purified toxins of buckthorn (Karwinskia humboldtiana).

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To determine the extent of extraneural lesions in buckthorn poisoning, 180 CD1 mice were administered either green or ripe fruit or toxins T-544 or T-514 obtained from the fruit of the plant and were observed over a period of three weeks. Marked weakness, hyporeflexia, hair bristling, ptosis, spinal

Buckthorn neuropathy in vitro : evidence for a primary neuronal effect.

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The neuropathy produced by toxins isolated from the buckthorn shrub (Karwinskia humboldtiana) has previously been proposed as a model for primary PNS demyelination in vivo. These toxins have been suggested to act through a metabolic effect on the Schwann cell. The aim of the present study was to use

Depression of fast axonal transport in axons demyelinated by intraneural injection of a neurotoxin from K. humboldtiana.

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Tullidinol, a neurotoxin extracted from the Karwinskia humboldtiana fruit, dissolved in peanut oil was injected into the right sciatic nerve of adult cats. The contralateral sciatic nerve received an equivalent volume of peanut oil alone. The fast axonal transport of labeled ([3H]Leucine) protein

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Herbal & Natural Medicine

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