mandelic acid/krabbamein

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Synthesis and Molecular Simulation Studies of Mandelic Acid Peptidomimetic Derivatives as Aminopeptidase N Inhibitors

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Background: The aminopeptidase N (APN) over-expressed in tumor cells plays a critical role in angiogenesis which makes the development of APN inhibitors an attractive strategy for cancer research. Aims

Anti-tumor promoting effect of glycosides from Prunus persica seeds.
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Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and

Pigmented Pheochromocytoma: an Unusual Variant of a Common Tumor.
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Pheochromocytoma is a neuroendocrine tumor arising from the adrenal medulla. A number of variants of pheochromocytoma are known; however, pigmented pheochromocytoma is extremely rare, with only few cases reported in literature. We report the cases of two patients with pigmented pheochromocytoma.

Recurrent operated malignant pheochromocytoma.
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Pheochromocytoma was diagnosed in a female patient aged 26 with paroxysmal arterial hypertension (AH), profuse sweating, headache, anxiety, tachycardia, transit arrhythmia, high urinary norepinephrine (NE), epinephrine (E) and vanillyl mandelic acid (VMA). Urography with intravenous Odiston revealed

[Catecholamine metabolism. Physiopathology and pathobiochemistry].
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Metabolic studies on isolated rat organs showed that vanillyl mandelic acid (VMA) is dehydrogenated by liver homogenate and suspension of pseudomonas fluorescens. In the 100000 g supernatant fraction of homogenated rat kidneys enzymatic activity was sufficient for kinetic studies and the examination

Enantiomeric NMR discrimination of carboxylic acids using actinomycin D as a chiral solvating agent.
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Actinomycin D (Act-D) is a biologically important polypeptide antibiotic clinically used to treat several malignant tumors. Herein, we extended its hitherto-unexplored application as an applicable chiral solvating agent (CSA) for the rapid enantiomeric determination of different chiral carboxylic

Genetic effects and biotoxicity monitoring of occupational styrene exposure.
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Styrene is a commercially important chemical widely used in the manufacture of synthetic rubber, resins, polyesters, and plastics. The highest levels of human exposure to styrene occurs in occupational settings, especially during the production of reinforced plastic products, which involve manual

Novel structural motifs consisting of chiral thiazolines: synthesis, molecular recognition, and anticancer activity.
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The facile synthesis of linear and cyclic chiral oligo(4-alpha/beta-methyl)thiazolines is described. Linear oligothiazolines have been efficiently synthesized by the iterative formation of thiazoline rings and two-directional block condensation. The construction of 24- to 36-membered cyclic

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