The experimental group will drink twice daily 2 tea bags of Moringa oleifera tea (Kanhye brand) infused in 200 ml of hot water (during 5 minutes) for a period of 4 weeks. The locally available Moringa tea with the international certification by ECOCERT France will be used in this study.

The control group will receive instructions to consume 200 ml of plain water twice daily for a period of 4 weeks.

Metabolic Syndrome

4 grams of Moringa oleifera tea twice daily

Moringa oleifera tea

University of Mauritius

Effect of Moringa Oleifera Infusion on Health

Randomized Clinical Study Investigating the Effect of Moringa Oleifera Infusion on Bioclinical Parameters of Health

Change will be determined as the value at Day 29 with respect to Day 1 for Phase 1 (Four weeks) and for Phase 2 (four weeks)

Levels of blood anti-oxidants (superoxide dismutase, glutathione peroxidase, total blood anti-oxidant capacity) will be monitored every fortnight during the 8-week clinical trial. C-Reactive Protein will also be measured.

CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.

MChanSun

Associate Professor

This randomized clinical study will consist of two parallel groups with a crossover design.
There will be two arms as follows:
Intervention group [Drinking Moringa tea]
Control group [Drinking plain water].
Computer-generated random numbers will be used for simple randomization of subjects to either the experimental or control group.
With the cross over design, there will be two phases with an interchange of the groups during Phase 1 and 2 as follows:
Four-week Phase 1 - Group A drinking Moringa tea v/s Group B drinking plain water One-week washout Four-week Phase 2 - Group A drinking plain water v/s Group B drinking Moringa tea

A coding system will be used whereby each subject will be attributed a code upon signing the consent form. Only the Principal Investigator assisted by a second investigator will have access to the name-code list.

HIV positive patients on nevirapine containing regimen, taking Moringa oleifera leaf powder

HIV positive patients on efavirenz containing regimen, taking Moringa oleifera

HIV positive patients on nevirapine containing regimen, taking Moringa oleifera leaf powder
Moringa oleifera: leaf powder, 1.85g once daily as hard gelatin capsules

Nevirapine

HIV positive patients on efavirenz containing regimen, taking Moringa oleifera
Moringa oleifera: leaf powder, 1.85g once daily as hard gelatin capsules

Efavirenz

Total

Sex: Female, Male

Weight

Area under the plasma concentration time curve, determined using a non-compartmental approach by means of the Phoenix WinNonlin software application. Time points for sample collection were 0.5, 1, 1.5, 2, 3, 4, 6, 8 and 12 h

HIV positive patients on nevirapine containing regimen, taking Moringa oleifera leaf powder
Moringa oleifera: leaf powder

HIV positive patients on efavirenz containing regimen, taking Moringa oleifera
Moringa oleifera: leaf powder

plasma concentration 12h post dose, determined using a non-compartmental approach by means of the Phoenix WinNonlin software application. Time points for sample collection were 0.5, 1, 1.5, 2, 3, 4, 6, 8 and 12 h

C12h

Maximum plasma concentration post does, determined using a non-compartmental approach by means of the Phoenix WinNonlin software application. Time points for sample collection were 0.5, 1, 1.5, 2, 3, 4, 6, 8 and 12 h

Cmax

HIV positive patients on efavirenz containing regimen, taking Moringa oleifera leaf powder

Washout Day 0

Baseline Day 22

Day 35

Tsitsi G Monera-Penduka

leaf powder, 1.85g once daily, hard gelatin capsules

moringa rivae/andoxunarefni

Effect of Moringa Oleifera Infusion on Health

Moringa Oleifera- Antiretroviral Pharmacokinetic Drug Interaction

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