normorphine/kannabis

Krækjan er vistuð á klemmuspjaldið

GreinarKlínískar rannsóknirEinkaleyfi

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Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP.

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Cannabinoid receptor agonists inhibit electrically evoked isometric contractions of the myenteric plexus--longitudinal muscle preparation of the guinea-pig small intestine (MPLM), probably by reducing release of acetylcholine (ACh) through the activation of prejunctional CB1 receptors. As CB1

Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist.

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1. Methyl arachidonyl fluorophosphonate (MAFP) (1 microM) significantly attenuated the ability of WIN 55,212-2, CP 55,940, (-)-delta 9-tetrahydrocannabinol (THC), nabilone and (R)-(+)-arachidonoyl-1'-hydroxy-2'-propylamide (methanandamide) to inhibit electrically-evoked isometric contractions of the

Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus.

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1. The dose-related inhibition of the twitch responses of the myenteric plexus-longitudinal muscle preparation of the guinea-pig small intestine by cannabinoid (CB) agonists, (+)-WIN 55212 and CP 55940 during stimulation at 0.1 Hz with supramaximal voltage was confirmed. These agonists inhibited

Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine.

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1. CP 50,556, CP 55,940, nabilone, CP 56,667, delta 9 -tetrahydrocannabinol (THC) and cannabinol each inhibited electrically-evoked contractions of the myenteric plexus-longitudinal muscle preparation of guinea-pig small intestine in a concentration-related manner. The IC50 values of these

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Herbal & Natural Medicine

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