ocular hypertension/albumin

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Reduced plasma cortisol binding to albumin in ocular hypertension and primary open-angle glaucoma.

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OBJECTIVE To compare plasma cortisol binding as well as total plasma cortisol, free cortisol and percent free cortisol in normals, ocular hypertensives and primary high pressure open-angle glaucomas. METHODS Blood samples were obtained on outpatient visits of 18 normals, 19 ocular hypertensives and

Melanopsin-Containing or Non-Melanopsin-Containing Retinal Ganglion Cells Response to Acute Ocular Hypertension With or Without Brain-Derived Neurotrophic Factor Neuroprotection.

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To analyze the responses of different retinal ganglion cell (RGC) types to acute ocular hypertension (AOH) and intravitreal administration of brain-derived neurotrophic factor (BDNF). In adult albino rats, the anterior chamber of the left eye was cannulated with a needle connected to a saline

Animal model for uveitic glaucoma.

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BACKGROUND This study was carried out in order to improve the understanding of the pathogenesis of uveitic glaucoma. METHODS Uveitis was induced in 48 Lewis rats by S-antigen injection. Intraocular pressure (IOP) was measured by Tono-Pen-2 daily for 24 days in 16 animals. Histopathology was

An overview of SR121463, a selective non-peptide vasopressin V(2) receptor antagonist.

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SR121463 is a selective, orally active, non-peptide antagonist of vasopressin (AVP) V(2) receptors with powerful aquaretic properties in various animal species and humans. SR121463 belongs to a new class of drugs, called aquaretics, which are capable of inducing free-water excretion without

Misoprostol therapeutics revisited.

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Misoprostol, a prostaglandin E1 analog, is a racemate of four stereoisomers. On administration it rapidly de-esterifies to its active form, misoprostolic acid. Misoprostolic acid is 85% albumin bound and has a half-life of approximately 30 minutes. It is excreted in urine as inactive metabolites. No

Prognosis and acute complications at the first onset of idiopathic nephrotic syndrome in children: a nationwide survey in Japan (JP-SHINE study).

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Information on the epidemiology of idiopathic nephrotic syndrome (INS) in children, complications of INS and the side effects of steroid therapy is scarce.The Japanese Pediatric Survey Holding Information of Nephrotic Syndrome, a nationwide cohort study,

Evaluation of dynamic thiol-disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis.

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The aim of this study was to evaluate thiol/disulfide homeostasis and ischemia-modified albumin levels with primary open-angle glaucoma, ocular hypertension, and control group; also to interpret the correlation between these biochemical parameters and retinal nerve fiber layer

Histamine-Induced Conjunctivitis and Breakdown of Blood-Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics.

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Conjunctival inflammation disturbs the blood-tear barrier and thus affects the tear film stability and composition. We aimed to develop a non-invasive and reliable method to induce conjunctivitis in dogs, a large animal model for translational work on ocular surface disease in humans. Six beagle

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