190 mg souroubea-platanus preparation in vegicap. Administered once daily for 14 days.

380 mg souroubea-platanus preparation in vegicap. Administered once daily for 14 days.

Inert placebo in an identical vegicap to the experimental treatment groups. Administered once daily for 14 days.

Anxiety

Stress, Psychological

Extracts of S. Sympetala and P. occidentalis.

Souroubea-Platanus Preparation

Placebo

The Royal's Institute of Mental Health Research (IMHR) affiliated with the University of Ottawa

Safety, Tolerability and Behavioural Effects of Souroubea-Platanus in Healthy Volunteers

Systolic and Diastolic Blood pressure (mmhg)

Serum GGT; Gamma glutamyl transferase (U/L)

Serum AST; Aspartate aminotransferase (U/L)

Serum ALT ; Alanine aminotransferase (U/L)

Urinalysis; visual inspection, and microscopic visual examination if abnormal results present during visual inspection or on any of the chemistry panels.

The DSM-5 Level 2 Anxiety Adult measure has 7 items that assesses the domain of anxiety in individuals age 18 and older. All items are rated on a 5-point scale. Higher scores indicate greater anxiety. The DSM-5 Self-rated Level 2 Anxiety has a minimum score of 7 and a maximum score of 35.

The State-Trait Anxiety Inventory (STAI) has 20 items for assessing trait anxiety and 20 for state anxiety. All items are rated on a 4-point scale. Higher scores indicate greater anxiety. The STAI has a score range of 20-80, with a minimum score of 20 and a maximum score of 80.

platanus occidentalis/kalín

Safety, Tolerability and Behavioural Effects of Souroubea-Platanus in Healthy Volunteers

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum