the study involves the intake of two capsules per day, one capsule to be taken before breakfast and one before dinner for a period of 6 weeks of a nutritional supplement
INTERVENTION CAPSULE COMPOSITION active substances for 2 capsules Bio Curcumin 400 mg Polydatin 00 mg Beta-Caryophyllene 48 mg

particpants included in the placebo group will take two capsules per day (containing no bioactive compound, only hydroxypropyl methylcellulose, gellan gum, pigment), one capsule to be taken before breakfast and one before dinner for a period of 6 weeks.

Osteoarthritis

Knee Pain Chronic

two capsules per day, one capsule to be taken before breakfast and one before dinner for a period of 6 weeks.

Experimental: Curcumin derivate

two capsules per day (containing no bioactive compound, only hydroxypropyl methylcellulose, gellan gum, pigment), one capsule to be taken before breakfast and one before dinner for a period of 6 weeks.

Placebo

Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis

Evaluation of the Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in People With Osteoarthritis

WOMAC scale is a self-administered questionnaire consisting of 24 items divided into 3 subscales:
Pain (5 items): during walking, using stairs, in bed, sitting or lying, and standing upright Stiffness (2 items): after first waking and later in the day Physical Function (17 items): using stairs, rising from sitting, standing, bending, walking, getting in / out of a car, shopping, putting on / taking off socks, rising from bed, lying in bed, getting in / out of bath, sitting, getting on / off toilet, heavy domestic duties, light domestic duties
The test questions are scored on a 0-4 scale, corresponding to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4).
The scores for each subscale are summed up; higher scores on the WOMAC indicate worse pain, stiffness, and functional limitations

Serum CRP levels were assessed by means of a commercially available CRP enzyme immunoassay

Levels of TNF-alpha, IL-1beta, IL-6, nitrates/nitrites will be evaluated by means of ELISA-testing

Painkillers utilization will be registered on a daily basis by participants, indicating dosage and daily frequency of use.

KOS Care SRL - Istituto di Riabilitazione Santo Stefano

Symptomatic patients with laparoscopic diagnosis of endometriosis

Endometriosis

Chronic Pelvic Pain

Palmitoylethanolamide 600 mg twice daily for 10 days sublingually and oral palmitoylethanolamide 400 mg and polydatin 40 mg, twice daily for 90 days

Administration of micronized Palmitoylethanolamide (PEA)- Transpolydatin

University of Cagliari,Obstetrics and Gynecological Department,

Efficacy of Palmitoylethanolamide-polydatin Combination on Chronic Pelvic Pain in Patients With Endometriosis

Pilot Study About Efficacy of Palmitoylethanolamide-polydatin Combination on Chronic Pelvic Pain in Patients With Laparoscopic Diagnosis of Endometriosis

Stefano Angioni

Associate Professor

University of Cagliari

Recoclix: two tablets per day for 12 weeks

Irritable Bowel Syndrome

tablets; 200 mg PEA+20 mg polydatin; 2 tablets/day; 12 weeks

Recoclix

Dept Internal Medicine and Gastroenterology, Policlinico Sant'Orsola-Malpighi

Safety and Efficacy Study of PEA and Polydatin on Intestinal Inflammation and Visceral Hyperalgesia in IBS Patients

Effect of the Oral Administration in IBS Patients of the Association of 200 mg Micronised Palmitoylethanolamide (PEA) and 20 mg Polydatin, on Parameters of Intestinal Inflammation and Visceral Hyperalgesia.

Comparison between healthy volunteers and IBS patients (screening visit) on the following parameters:
number of infiltrating mast cells (ICH)
mast cell activation, as per histamine and tryptase release in the surnatant of cultured colon biopsy samples
Comparison between active and placebo supplemented IBS patients (after 12 weeks from randomization) on the following parameters:
number of infiltrating mast cells (ICH)
mast cell activation, as per histamine and tryptase release in the surnatant of cultured colon biopsy samples

Comparison between active and placebo supplemented IBS patients (after 12 weeks from randomization) on the level of anandamide, 2-AG, PEA, CB1, CB2, FAAH (LC-APCI-MS; immunoblotting)

Comparison between active and placebo supplemented IBS patients (after 12 weeks from randomization) of the number of other inflammatory cell subsets (ICH)

Laboratory test (blood cell count, AST, ALT, creatinine, gamma-GT, alkaline phosphatase, total bilirubin, glucose, N, Na, K, Ca)
Physical examination and vital signs (systolyc and diastolic blood pressure, heart rate, respiratory rate)

polydatin/bólga

Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis

Efficacy of Palmitoylethanolamide-polydatin Combination on Chronic Pelvic Pain in Patients With Endometriosis

Safety and Efficacy Study of PEA and Polydatin on Intestinal Inflammation and Visceral Hyperalgesia in IBS Patients

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum