sickle cell trait/albumin

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Albuminuria in Afro-Caribbeans with Type 2 diabetes mellitus: is the sickle cell trait a risk factor?

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OBJECTIVE To determine the prevalence of albuminuria [raised albumin-creatinine ratio (ACR)] in an out-patient population of Afro-Caribbeans with Type 2 diabetes mellitus (DM) and to determine if the possession of the sickle cell trait (SCT) is a risk factor. METHODS The ACR in a morning urine

Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.

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OBJECTIVE The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE To describe the relationship between SCT and CKD and albuminuria in self-identified African Americans. METHODS Using 5 large, prospective, US population-based studies (the

Reversing the tide - diagnosis and prevention of T2DM in populations of African descent.

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Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). The burden of T2DM is amplified by diagnosis after preventable complications of the disease have occurred. Earlier detection would result in a reduction in undiagnosed T2DM, more

The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability

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Hemoglobin A1c (HbA1c) is a popular invaluable tool in the diagnosis of Type 2 diabetes for red blood cells (RBCs) with a lifespan of 120 days; however, many factors, including hemoglobinopathies, affect its accuracy. Sickle cell trait, primarily a benign medical condition, is a point mutation in

An unusual cause of intestinal failure.

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A 62-year-old man presented to the emergency department with 5 weeks of worsening lower abdominal pain associated with watery diarrhoea, vomiting and 10% loss of body weight. He had recently experienced night blindness. There was no history of foreign travel. His past medical history

Sickle cell gene and liver functions in a Sudanese population.

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401 subjects of both sexes and with ages ranging from 5 to 50 years were investigated for haemoglobin phenotypes by starch-gel electrophoresis. Concentrations of blood haemoglobin, serum total protein, albumin, globulin, total cholesterol and serum transaminases (SGOT and SGPT) were determined to

Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study.

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Background Malaria exposure in childhood may contribute to high blood pressure ( BP ) in adults. We used sickle cell trait ( SCT ) and α⁺thalassemia, genetic variants conferring partial protection against malaria, as tools to test this hypothesis. Methods and Results Study sites were

Cardiorenal risk prevalence in sickle cell hemoglobinopathy.

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BACKGROUND The spectrum of kidney functional and structural alterations in sickle cell hemoglobinopathy (SCH) is broad. Also, morbidity and mortality from end organ dysfunction, especially cardiorenal dysfunction, are substantial. Consequently, screening an SCH population prospectively for surrogate

African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos.

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African ancestry alleles may contribute to CKD among Hispanics/Latinos, but whether associations differ by Hispanic/Latino background remains unknown. We examined the association of CKD measures with African ancestry-specific APOL1 alleles that were directly genotyped and sickle cell trait

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