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[Synthesis and anti-inflammatory activity of p-(methanesulfonyl) styrene-linked cyclic ketone derivatives].

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OBJECTIVE To search for new compounds with strong anti-inflammatory activity and low gastrointestinal (GI) side effects. METHODS A series of p-(methanesulfonyl) styrene-linked cyclic ketone derivatives were synthesized. Their anti-inflammatory activities against xylene-induced mice ear swelling and

Inhibition of carrageenin-induced paw edema by a superoxide dismutase derivative that circulates bound to albumin.

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Although the possible involvement of superoxide radical and its metabolite(s) in the pathogenesis of various types of edema have been suggested, direct evidence supporting this concept is lacking. Since intravenously administered Cu2+Zn2(+)-type superoxide dismutase (SOD) rapidly disappeared from

The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage.

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The coagulation cascade has a potential role in brain edema formation due to intracerebral hemorrhage. In this study blood and other solutions were injected stereotactically into the right basal ganglia in rats. Twenty-four hours following injection, brain water and ion contents were measured to

Physical characteristics, pharmacological properties and clinical efficacy of the ketoprofen patch: a new patch formulation.

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OBJECTIVE The mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs), to which ketoprofen belongs, is based on their cyclo-oxigenase (COX) inhibiting action, concerning both subtype COX-1 constitutive isoform and COX-2 inducible isoform. Ketoprofen administration may be carried out by

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Herbal & Natural Medicine

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