taspine/brjóstakrabbamein

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GreinarKlínískar rannsóknirEinkaleyfi

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Synthesis of novel taspine diphenyl derivatives as fluorescence probes and inhibitors of breast cancer cell proliferation.

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Two novel taspine diphenyl derivatives (Ta-dD) were designed and synthesized by introducing different coumarin fluorescent groups into the basic structure of Ta-dD. The main advantage of these two compounds is that they can be used as fluorescence probes and inhibitors simultaneously. In the present

Activity of taspine isolated from Radix et Rhizoma Leonticis against estrogen-receptor-positive breast cancer.

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The aim of our study was to investigate the effect of taspine isolated from Radix et Rhizoma Leonticis on the growth of oestrogen-receptor-positive breast cancer xenografts in vivo and the possible mechanism for this action. In vivo taspine studies were conducted with ZR-75-30 human breast cancer

A novel taspine derivative, HMQ1611, inhibits breast cancer cell growth via estrogen receptor α and EGF receptor signaling pathways.

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Breast cancer is a common cancer with a leading cause of cancer mortality in women. Currently, the chemotherapy for breast cancer is underdeveloped. Here, we report a novel taspine derivative, HMQ1611, which has anticancer effects using in vitro and in vivo breast cancer models. HMQ1611 reduced

A novel taspine derivative, HMQ1611, suppresses adhesion, migration and invasion of ZR-75-30 human breast cancer cells.

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BACKGROUND Taspine was screened for the first time from Radix et Rhizoma leonticis (Hong Mao Qi in Chinese) using cell membrane chromatography in our laboratory. Its anticancer and antiangiogenic properties were demonstrated, and it could serve as a lead compound in anticancer agent development.

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Herbal & Natural Medicine

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