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Outcomes in an obstetrical population with hereditary thrombophilia and high tobacco use.

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OBJECTIVE The purpose of this study was to examine birth outcomes in women treated or untreated for thrombophilia during pregnancies affected or not by tobacco exposure. METHODS This was a retrospective cohort study of consecutive women from a single maternal fetal medicine clinic who delivered

Selected Aspects of Tobacco-Induced Prothrombotic State, Inflammation and Oxidative Stress: Modeled and Analyzed Using Petri Nets.

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Many factors, such as endothelial dysfunction, inflammation and hemostatic disturbances, affect formation and progression of atherosclerotic plaque. In our study, we have focused on hemostatic disturbances with particular emphasis on the extrinsic pathways of coagulation. Thrombin is a main enzyme

Influence of Tobacco Smoking on Perioperative Risk of Venous Thromboembolism.

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Venous thromboembolism (VTE) is generally considered a process very different from arterial atherosclerosis. The role of tobacco is well known in arterial thrombosis. However, its role in VTE is less obvious and remains controversial. In this mini review, we analysed the literature to identify the

The Use of Direct Oral Anticoagulants in the Management of Venous Thromboembolism in Patients With Obesity

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Introduction The use of direct oral anticoagulants (DOACs) has gained significant traction given the lack of therapeutic monitoring and the need for anticoagulant bridging. There is a paucity of data on their effectiveness in obese patients with venous thromboembolism (VTE). Preliminary subgroup and

Effects of pentoxyfilline and heparin on reperfusion injury island skin flaps in rats exposed to tobacco.

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BACKGROUND Ischemia-reperfusion injury is believed to be a major cause of transferred skin flap failure. Cigarette smoking is known to be associated with endogenous antioxidant depletion, hypercoagulability, and cutaneous vasoconstriction. This investigation was carried out to study possible effects

[Tobacco: an atherogenic, thrombogenic or spasmogenic factor?].

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Smoking is one of the major causes of morbidity and mortality in the developed world. The main cause of death related to smoking is myocardial infarction. Smoking not only accelerates the process of atherosclerosis but also predisposes to acute complications, early in atheromatous disease, and which

[Hypercoagulable workup in ophthalmology. When and what].

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Most ophthalmologic disorders secondary to hypercoagulabe state are due to the confluence of congenital and adquired factors. A systematic workup is mandatory. Most of congenital coagulation disorders cause venous trombosis and are inherited autosomal dominantly. In order of frequency these are

CYP1A1, smoking and venous thromboembolism.

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Since CYP1A1 enzyme is involved in metabolism of tobacco carcinogens, the CYP1A1 gene may be of relevance to smoking-induced differences in the risks of venous thromboembolism (VTE). We conducted a case-control study to investigate genetic polymorphisms in CYP1A1 that might modify the risk of

Evaluation of the SAMe-TT2R2 score to predict the quality of anticoagulation control in a cohort of patients with venous thromboembolism treated with vitamin K antagonists.

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OBJECTIVE The SAMe-TT2R2 score has been recently proposed to predict the quality of anticoagulation control in patients with atrial fibrillation treated with vitamin K antagonists (VKA). We aimed at calculating this score in a cohort of patients with Venous Thromboembolism (VTE) and determine its

Venous Thromboembolism following Elective Aesthetic Plastic Surgery: A Longitudinal Prospective Study in 1254 Patients.

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Background. Venous thromboembolism (VTE) is a disorder with short-term mortality and long-term morbidity. Healthy patients submitted to elective aesthetic plastic surgeries (EAPS) have risk factors to develop VTE not well established yet. The objective of this study was to examine the incidence and

Common characteristics of patients diagnosed with upper-extremity venous thromboembolism during hospitalization: a descriptive study.

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OBJECTIVE The aim of this study was to explore the common characteristics of patients diagnosed with upper-extremity venous thromboembolism (UEVTE) during hospitalization. METHODS This was a retrospective chart review. METHODS This study was performed at a Midwest multisite hospital of 5 acute-care

Venous Thromboembolism Incidence After Craniofacial Surgery.

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BACKGROUND Current protocols for venous thromboembolism (VTE) prophylaxis after craniofacial surgery (CFS) vary widely with substantial disagreements in both indications and managements. An evidence-based approach to this issue requires the following: the incidence of postoperative VTE,

Incidence and predictors of venous thromboembolism after debulking surgery for epithelial ovarian cancer.

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OBJECTIVE The aim of this study was to determine the incidence and the risk factors of venous thromboembolism (VTE) within 30 days after primary surgery for epithelial ovarian cancer (EOC). METHODS In a historical cohort study, we estimated the postoperative 30-day cumulative incidence of VTE among

Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages.

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OBJECTIVE To investigate whether exposure of human monocytes/macrophages to tobacco smoke induces their release of membrane microvesicles (MVs) that carry tissue factor (TF) released from cells, whether smoke-induced MVs are procoagulant, and what cellular processes might be responsible for their

Postoperative Venous Thromboembolism and other Complications after Anatomic Total Shoulder Arthroplasty in Patients With a History of Prostate or Breast Cancer.

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As cancer treatments continue to improve the overall survival rates, more patients with a history of cancer will present for anatomic total shoulder arthroplasty (TSA). Therefore, it is essential for orthopaedic surgeons to understand the differences in care required by this growing

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