veratridine/seizures

Krækjan er vistuð á klemmuspjaldið

GreinarKlínískar rannsóknirEinkaleyfi

Veldu tegund tegund

Bls 1 frá 43 niðurstöður

Veratridine induced absence like-seizure in the freely moving rats: a study correlating the behavioural findings with the electrophysiological activities.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

OBJECTIVE Veratridine was characterized previously as an experimental model of epilepsy in vitro. The aim of this preliminary investigation is to identify the pattern of seizure induced by this model in vivo. METHODS Veratridine (200 μg/kg) was administered intraperitoneally to male Sprague-Dawley

Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

OBJECTIVE Stroke patients are at a high risk of developing post-ischemic seizures and cognitive impairment. Nefiracetam (NEF), a pyrrolidone derivative, has been shown to possess both anti-epileptic and cognitive-enhancing properties. In this study the anti-seizure effects of NEF were evaluated in a

Veratridine-induced wet dog shake behaviour and apoptosis in rat hippocampus.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

We have previously evaluated veratridine as an in vitro model of seizure using conventional electrophysiological recordings in rat hippocampal CA1 pyramidal neurones. The aim of this investigation is to further characterize this convulsant as an in vivo model of seizure. Veratridine was administered

Overproduction of voltage-dependent Na+ channels in the developing brain of genetically seizure-susceptible E1 mice.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

We used E1 mice, a ddY mouse-derived, autosomal mutant strain and a model of hereditary sensory-precipitated epilepsy, to test the hypothesis that epileptic susceptibility may be associated with the activity of voltage-dependent ion channels. We examined the saxitoxin binding capacity of the

Epileptiform activity of veratridine model in rat brain slices: effects of antiepileptic drugs.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

The effects of the antiepileptic drugs valproic acid (VPA), phenytoin (PHT), and ethosuximide (ESM) on evoked and spontaneous seizure-like (epileptiform) activity were studied in the veratridine epileptiform model in rat brain slices, using conventional electrophysiological intracellular recording

Effect of carbamazepine, oxcarbazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

Lamotrigine, carbamazepine and oxcarbazepine inhibit veratrine-induced neurotransmitter release from rat brain slices in concentrations corresponding to those reached in plasma or brain in experimental animals or humans after anticonvulsant doses, presumably due to their sodium channel blocking

Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

Nefopam (NEF) is a known analgesic that has recently been shown to be effective in controlling both neuropathic pain and convulsions in rodents. In this study we compared nefopam to carbamazepine (CBZ), a reference antiepileptic drug (AED), for their ability to protect cerebellar neuronal cultures

Depolarization block of neurons during maintenance of electrographic seizures.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

Epileptic seizures are associated with neuronal hyperactivity. Here, however, we investigated whether continuous neuronal firing is necessary to maintain electrographic seizures. We studied a class of "low-Ca2+" ictal epileptiform bursts, induced in rat hippocampal slices, that are characterized by

Pentylenetetrazole-induced seizure activity produces an increased release of calcium from endoplasmic reticulum by mediating cyclic AMP-dependent protein phosphorylation in rat cerebral cortex.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

1. To determine the involvement of the convulsant agent pentylenetetrazole (PTZ) in intracellular calcium release in neurons, its effect on stored calcium in the endoplasmic reticulum of rat cortical neurons was tested. 2. Intraperitoneal injection of PTZ caused marked release of calcium from the

Reduced signal complexity of intracellular recordings: a precursor for epileptiform activity?

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

Recent studies have shown that time windowed extraction of nonlinear parameters like an effective correlation dimension from intracranially recorded EEG of epileptic patients often allows to detect and identify an unequivocal "pre-ictal phase" preceding an epileptic seizure. In another study,

Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

Studies conducted by Fisons Pharmaceuticals and the Antiepileptic Drug Development Program (ADD Program) of the Epilepsy Branch (NINDS, NIH) revealed that 'remacemide' (FPL 12924, formerly PR 934-423) was effective orally in the prevention of maximal electroshock seizures (MES) in rats. In this

The anticonvulsant effects of the enantiomers of losigamone.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

1 Losigamone is a novel anticonvulsant undergoing phase III clinical trials in patients with partial and secondary generalized seizures. This study investigated the effects of the S(+)- and R(-)- enantiomers of losigamone on endogenous amino acid release from BALB/c mouse cortical slices,

Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

Veratridine causes deplorization of excitable cells and produces marked elevation of adenosine 3',5'-monophosphate (cyclic AMP) and guanosine 3',5'-monophosphate (cyclic GMP) levels in incubated slices of mouse cerebral cortex. Phenytoin, carbamazepine, phenobarbital, primidone, phensuximide,

The effect of losigamone (AO-33) on electrical activity and excitatory amino acid release in mouse cortical slices.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

1. Losigamone is a novel anticonvulsant the mechanism of action of which is not known. This study investigated the effect of losigamone on spontaneous, NMDA- and AMPA-induced depolarizations in the cortical wedge preparation of the DBA/2 mouse (which are susceptible to sound-induced seizures) and on

Iodine labelling of sea anemone toxin II, and binding to normal and denervated diaphragm.

Aðeins skráðir notendur geta þýtt greinar

Skráðu þig / skráðu þig

1. Sea anemone toxin II (ATX II) which keeps the activated sodium channels open, can be labelled at its histidine residues with 125I up to a specific radioactivity of 500 Ci/mmole. Upon intraventricular injection in mice, ATX II causes acute, short-lasting hyperexcitation and convulsions. Its LD50

Fyrri
1
2
3
Næst

Skráðu þig á
facebook síðu okkar

Herbal & Natural Medicine

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum

Virkar á 55 tungumálum
Jurtalækningar studdir af vísindum
Jurtaviðurkenning eftir ímynd
Gagnvirkt GPS kort - merktu jurtir á staðsetningu (kemur fljótlega)
Lestu vísindarit sem tengjast leit þinni
Leitaðu að lækningajurtum eftir áhrifum þeirra
Skipuleggðu áhugamál þitt og vertu vakandi með fréttarannsóknum, klínískum rannsóknum og einkaleyfum

Sláðu inn einkenni eða sjúkdóm og lestu um jurtir sem gætu hjálpað, sláðu jurt og sjáðu sjúkdóma og einkenni sem hún er notuð við.
* Allar upplýsingar eru byggðar á birtum vísindarannsóknum