vulvodynia/progesterone

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Steroid receptor expression and morphology in provoked vestibulodynia.

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OBJECTIVE This study was undertaken to survey the steroid receptor expression and morphology in the vulvar vestibular mucosa in women with provoked vestibulodynia. METHODS Fourteen patients and 25 controls without oral contraceptives were included. Vestibular biopsy specimens were obtained and

Expression of Estrogen-Related Receptors in Localized Provoked Vulvodynia.

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Eight percent of women suffer from vulvodynia, a chronic pain condition with unknown etiology. Inflammation and dysregulation of estrogen signaling have been suggested to play a role in the pathogenesis of localized provoked vulvodynia (LPV). Therefore, the aim of the study was to analyze protein

Histopathologic characteristics of menopausal vestibulodynia.

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OBJECTIVE To assess whether premenopausal and postmenopausal vestibulodynia have different histologic features. METHODS We conducted a retrospective analysis of vestibulectomy specimens from 21 women with postmenopausal vestibulodynia and compared them with 88 premenopausal patients (42 primary, 46

Differences in primary compared with secondary vestibulodynia by immunohistochemistry.

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OBJECTIVE To assess whether primary and secondary vestibulodynia represent different pathologic pathways. METHODS This was an analysis of archived vestibulectomy specimens from 88 premenopausal women with vestibulodynia (2002-2008). Patient records were reviewed to classify the type of

Persistent genital hyperinnervation following progesterone administration to adolescent female rats.

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Provoked vestibulodynia, a female pelvic pain syndrome affecting substantial numbers of women, is characterized by genital hypersensitivity and sensory hyperinnervation. Previous studies have shown that the risk of developing provoked vestibulodynia is markedly elevated following adolescent use of

Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study.

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OBJECTIVE The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients. METHODS In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with

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Herbal & Natural Medicine

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