Sensory Perception of Sweet Flavors in E-Cigarette

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Sponsor

Oregon State University

TEST CLINICO: NCT03332953

BioSeek: nct03332953

Parole chiave

nicotina

Astratto

Despite the explosive popularity of sweet flavored electronic cigarettes, there is little empirical evidence regarding how "sweet" flavors interact with different levels of nicotine to reduce its perceived bitterness and harshness, and thereby increase its appeal and additive potential. This study will serve to fill this knowledge gap through empirical psychophysical data that will determine the association between sweet flavor and nicotine and its link to the acceptance and rejection of vaped nicotine.

Descrizione

We will recruit current, healthy e-cigarette users between the ages of 18-35.This study will require 1 visit to the Oregon State University campus to partake in a 1 hour (approximate) testing session. During the testing session, participants will be asked to puff commercial e-cigarettes containing 9 commercially available e-liquid preparations.

Date

Ultimo verificato:	09/30/2019
Primo inviato:	11/01/2017
Iscrizione stimata inviata:	11/01/2017
Primo pubblicato:	11/05/2017
Ultimo aggiornamento inviato:	10/08/2019
Ultimo aggiornamento pubblicato:	10/10/2019
Data di inizio effettiva dello studio:	01/20/2018
Data di completamento primaria stimata:	06/11/2018
Data stimata di completamento dello studio:	06/11/2018

Condizione o malattia

Smoking

Intervento / trattamento

Other: E-cigarette

Fase

Gruppi di braccia

Braccio	Intervento / trattamento
Other: E-cigarette Subjects will be asked to vape various e-cigarettes at three concentrations of nicotine and sweet flavor (9 stimuli per subject). The subject will be asked to make ratings for the overall liking or disliking of the e-cigarette, followed by ratings on perceived intensities of sensations.	Other: E-cigarette Subjects will be asked to vape various e-cigarettes containing e-liquids at three concentrations of nicotine and sweet flavor (9 stimuli per subject).

Criteri di idoneità

Età idonea per lo studio	18 Years Per 18 Years
Sessi idonei allo studio	All
Accetta volontari sani	sì
Criteri	Inclusion Criteria: - Healthy adults between 18-35 years of age; have been vaping for at least 1 month; currently use an e-cigarette that contains nicotine; have used an e-cigarette with medium (9-12 mg/mL) or high (18 to 36 mg/mL) nicotine strength at some point in their e-cigarette using history. Exclusion Criteria: - Do not have mouth or throat problems that would keep subject from vaping comfortably; do not have health problems that would keep subject from tasting or smelling normally; do not have any food ingredient allergies and have never had an allergic reaction to propylene glycol or vegetable glycerin; do not have any respiratory allergies (i.e., frequent sneezing, nasal congestion, nasal discharge); do not have a history of pulmonary disease or asthma; are not in the process of trying to quit vaping; are not pregnant, breast feeding, or trying to become pregnant.

Risultato

Misure di esito primarie

1. Hedonic and Intensity Ratings [Until July 2018]

The outcome will be ratings obtained for liking or disliking of the stimulus and ratings for perceived intensities of sensations. These quantitative values collected from the scaling procedure will be analyzed corresponding to the level of nicotine and flavor for the particular stimulus. For rating perceived intensity, we will use the general Labeled Magnitude Scale (gLMS), developed for measurement of the intensity of oral sensation and taste. The scale is bounded by 'no sensation' at the bottom to 'strongest imaginable sensation of any kind' on top, with intermediate ratings between (bottom to top: barely detectable, weak, moderate, strong, very strong). A Labeled Hedonic Scale (LHS) will be used to measure individuals' liking or disliking of the oral sensation. The scale encompasses from "most disliked sensation imaginable" on one end to "most liked sensation imaginable" on the other end, with intermediate hedonic labels (like/dislike: slightly, moderately, very much, extremely).