Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)
Parole chiave
Astratto
Descrizione
The Women's Antioxidant and Folic Acid Cardiovascular Study tested the effects of vitamin C (500 mg/day), vitamin E (600 IU every other day), and/or beta carotene (50 mg every other day) on the risk of major cardiovascular events (a combined outcome of myocardial infarction, stroke, coronary revascularization, or cardiovascular death) among 8171 female health professionals at increased risk. Participants were 40 years or older with a history of cardiovascular disease or 3 or more cardiovascular risk factors and were followed for an average duration of 9.4 years, from 1995-1996 to 2005. In 1998, 5442 of these participants were further randomized to the B-vitamin intervention (a daily combination pill containing folic acid [2.5 mg], vitamin B6 [50 mg], vitamin B12 [1 mg]) and were followed for 7.3 years, from April 1998 through July 2005.
Date
| Ultimo verificato: | 06/30/2020 |
| Primo inviato: | 10/26/1999 |
| Iscrizione stimata inviata: | 10/26/1999 |
| Primo pubblicato: | 10/27/1999 |
| Ultimo aggiornamento inviato: | 07/12/2020 |
| Ultimo aggiornamento pubblicato: | 07/14/2020 |
| Data di inizio effettiva dello studio: | 04/30/1993 |
| Data di completamento primaria stimata: | 06/30/2005 |
| Data stimata di completamento dello studio: | 06/30/2005 |
Condizione o malattia
Intervento / trattamento
Behavioral: dietary supplements
Drug: vitamin C
Drug: vitamin E
Drug: beta-carotene
Drug: folic acid/Vitamin B6/Vitamin B12
Fase
Criteri di idoneità
| Età idonea per lo studio | 40 Years Per 40 Years |
| Sessi idonei allo studio | Female |
| Accetta volontari sani | sì |
| Criteri | Women, aged 40 and over, at high risk, with a history of cardiovascular disease or three or more coronary heart disease risk factors. |
Risultato
Misure di esito primarie
1. Cardiovascular disease [undefined]
2. Cancer [undefined]
