Chinese Journal of Natural Medicines 2014-Sep
Heteroclitins R-S: new dibenzocylooctadiene lignans from Kadsura heteroclita.
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OBJECTIVE
To study the dibenzocylooctadiene lignans from the stems of Kadsura heteroclita.
METHODS
Chromatographic separations of silica gel and semi-preparative HPLC were used. All of the structures were elucidated on the basis of spectroscopic analysis, including 2D-NMR and HR-MS techniques.
RESULTS
Four dibenzocylooctadiene lignans were isolated from K. heteroclita. Their structures were identified as heteroclitin R (1), heteroclitin S (2), gonisin O (3), and schisanlignone A (4).
CONCLUSIONS
Heteroclitin R (1) and heteroclitin S (2) are new natural lignans.
