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Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice.
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OBJECTIVE
The current study was designed to investigate the protective role of alkannin (ALK) on liver injury in diabetic C57BL/KsJ-db/db mice and explore its potential mechanisms.
METHODS
An oral glucose tolerance test (OGTT) was performed. The levels of insulin, alanine aminotransferase (ALT),
Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in an imiquimod-induced psoriasis mouse model.
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OBJECTIVE
To investigate the effect of β, β-dimethylacryloyl alkannin, a main component of Lithospermum erythrorhizon, on activated dendritic cells (DCs) in a psoriasis mouse model.
METHODS
BALB/c mice were used to establish the animal model for psoriasis-like skin lesion; alkannin at 10 mg/kg
Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation.
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The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown strong and explicit cancer cell-selectivity, which results in little toxicity toward normal tissues, and has been recognized as a potential, relatively safe anticancer agent. However, several cancers are resistant to the
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