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6 risultati
Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways.
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The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear
Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis.
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OBJECTIVE
To investigate the effect of boldine isolated from Litsea cubeba on collagen-induced arthritis (CIA) rats and explore the molecular mechanism predicted by network pharmacology.
METHODS
CIA rats were orally administered with boldine. The bone destruction of paws was analyzed by histologic
Lancifoliaine, a new bisbenzylisoquinoline from the bark of Litsea lancifolia.
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A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids--N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine--were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine,
Alkaloids of Litsea wightiana1.
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Six aporphine alkaloids glaucine, boldine, norboldine, isoboldine, norcorydine and laurotetanine have been isolated from the ethanolic extract of the stems of LITSEA WIGHTIANA in which spasmolytic, hypothermic and blood pressure lowering activities have been confirmed.
5-Hydroxytryptamine2A receptor binding activity of compounds from Litsea sessilis.
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A 96-well microplate filtration based 5-HT(2A) receptor-radioligand binding assay was optimized and adopted to carry out a bioassay-guided fractionation of the methanol extract of the leaves of Litsea sessilis. This purification led to the isolation of two compounds identified as (+)-boldine (1) and
[Alkaloids from roots and stems of Litsea cubeba].
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A phytochemical investigation on the roots and stems of Litsea cubeba led to the isolation of seven isoquinolone alkaloids. By spectroscopic analysis and comparison of their 1H and 13C-NMR data with those in literatures, these alkaloids were identified as (+)-norboldine (1), (+)-boldine (2),
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