cimifugin/saposhnikovia divaricata

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[Isolation and structure identification of chemical constituents from Saposhnikovia divaricata (Turcz.) Schischk].

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Fourteen compounds were isolated from the ethanol extraction of Saposhnikovia divaricata (Turcz.) Schischk using column chromatographic methods after enrichment by macroporous adsorptive resins. They were identified as fangfengalpyrimidine (1), clemiscosin A (2), 5-hydroxy-8-methoxypsoralen (3),

Three new compounds from the roots of Saposhnikovia divaricata.

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From the roots of Saposhnikovia divaricata, three new compounds, divaricataesters A (1), B (2), and C (3) were isolated, along with three known compounds, cimifugin (4), (3S)-2,2-dimethyl-3,5-dihydroxy-8-hydroxymethyl-3,4-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one (5) and

[Chemical constituents of roots of Saposhnikovia divaricata].

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OBJECTIVE To study the chemical constituents in the dried roots of Saposhnikovia divaricata. METHODS The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by IR, UV, MS and NMR evidences. RESULTS Eighteen compounds were obtained and identified

[Studies on the method for the processing roots of cultivated Saposhnikovia divaricata].

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OBJECTIVE To establishing a standard processing method for cultivated Saposhnikovia divaricata. METHODS Crude drug was dried at different temperature, and the contents of prim-O-glucosyl-cimifugin,cimifugin,4'-O-beta-glucosyl-5-O-methylvisamminol, sec-O-glucosyl-hamaudol in the processed crude drug

Preparative separation of chromones in plant extract of Saposhnikovia divaricata by high-performance counter-current chromatography.

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Four chromones, prim-O-glucosylcimifugin, 4'-O-β-D-glucosyl-5-O-methylvisamminol, cimifugin and sec-O-glucosylhamaudol, were isolated and purified from Saposhnikovia divaricata for the first time by high-performance counter-current chromatography (HPCCC) using a system consisting of ethyl

Intestinal permeability of the constituents from the roots of Saposhnikovia divaricata in the human Caco-2 cell monolayer model.

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The bidirectional intestinal permeability of the active constituents from the roots of Saposhnikovia divaricata, including four coumarins, anomalin (1), 5-methoxy-7-(3,3-dimethylallyloxy)coumarin (2), decursin (3), and decursinol angelate (4), as well as four chromones, cimifugin (5),

[Comparative study on quality of decoction pieces of Saposhnikovia divaricata with different growth patterns and years and thinking of standard of decoction pieces of S. divaricata in Chinese Pharmacopoeia].

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This study aims to compare the internal chemical composition and appearance indifferent growth patterns and years of Saposhnikovia divaricata decoction pieces,which was applied to explore the effect of growth patterns and years on its quality. The appearance characteristic data of 55 batches of

Chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. Growing in Buryatia and Mongolia and their cytotoxicity.

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Saposhnikovia divaricata (family Apiaceae) a traditional medicinal plant distributed in many provinces of China, is well known for the pharmaceutical value and has been used for rheumatic arthritis, and anxiety in children. Antiviral, antioxidant and antiproliferative activities were

Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2.

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Colorectal cancer ranks 3rd in terms of cancer incidence. Growth and development of colon cancer cells may be affected by juice and extracts from Saposhnikovia divaricata root. The objective of the research was to analyze the effect of S. divaricata juice and extracts on the viability,

Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions.

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Cimifugin is a bioactive component of Saposhnikovia divaricata, a Chinese herb for treating allergy. Our previous studies demonstrated that cimifugin inhibited allergic inflammation efficiently. This study aims to determine the mechanism of cimifugin on epithelial cells in allergic inflammation.

[Studies on quality specification standards for Saposhnicovia divaricata (Turcz.) Schischk].

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OBJECTIVE To work out a qualitative-quantitative standard for Saposhnikovia divaricata. METHODS TLC and HPLC were adopted. RESULTS Four chromone compounds were identified by TLC, and the contents of two chromone compounds were determined by HPLC. CONCLUSIONS Prim-O-glucosylcimifugin,

Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical.

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prim-O-Glucosylcimifugin (PGCN), a highest content chromone in the roots of Saposhnikovia divaricata, was incubated with human intestinal flora (HIF), and two biotransformation products were obtained from the incubated solution by chromatographic methods. The chemical structures of the two

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