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The carotenoid crocetin enhances pulmonary oxygenation.
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Rabbits anesthesized with urethan and subjected to mild hypoxia (60-70 Torr arterial PO2) through a reduction of the minute volume were injected with a carotenoid compound, crocetin, or saline. The increased PO2 in the arterial blood seen subsequently with crocetin is attributed to increased
Synthesis and cardiomyocyte protection activity of crocetin diamide derivatives.
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A series of novel diamide derivatives (2-8) of crocetin (1) were synthesized and evaluated for their cardioprotective activity in vitro. Using well-established model of hypoxia-induced injury in H9c2 cells, we investigated the effects of 9 compounds and positive drug nicorandil on cellular
Saffron and its derivatives, crocin, crocetin and safranal: a patent review.
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BACKGROUND
Saffron and its main components have traditionally been used as pharmaceutical agents. Current experimental research projects have also exhibited their applications in a wide spectrum of disorder treatments. Area covered: This review covers the demonstrated findings and patents on
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