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cyanocobalamin/sarcoma
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[Effect of cyanocobalamin, cobamide coenzyme and the cytostatic hispen on changes in cobalamin levels in healthy rats and rats with transplanted sarcoma M-1].
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The influence of cyanocobalamine (CN-B12), cobamide coenzyme (5'-deoxyadenosyl-B12, DBC) and the cytostatic hisphen on the level of cobalamines in the blood serum, liver, kidney, heart and in the tumor of healthy and sarcoma M-1 implanted rats was studied. In the above organs and tissues cobalamines
Tumor-host metabolic relationships: total levels and chromatographic pattern of vitamin B12 in serum, liver and tumor of Yoshida sarcoma-bearing rats.
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Total content of cobalamins was estimated by an isotopic dilution technique in serum and liver of Yoshida sarcoma-bearing rats and in a group of control rats. Total levels of vitamin B12 were also measured in neoplastic tissue. Hydroxycobalamin, adenosylcobalamin, cyanocobalamin and methylcobalamin,
Transcobalamin II receptor imaging via radiolabeled diethylene-triaminepentaacetate cobalamin analogs.
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Rapidly dividing cells up-regulate the number of transcobalamin II receptors during DNA replication. We have developed diethylene-triaminepentaacetate (DTPA) cobalamin analogs for the purpose of imaging transcobalamin II receptors in malignant and nonmalignant tissue.
METHODS
Methyl-, adenosyl- and
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