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Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
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The aim of the study was to investigate the protective effect of dioscin against APAP-induced hepatotoxicity. In the in vitro tests, HepG2 cells were given APAP pretreatment with or without dioscin. In the in vivo experiments, mice were orally administrated dioscin for five days and then given APAP.
Dioscin alleviates lipopolysaccharide-induced acute lung injury through suppression of TLR4 signaling pathways.
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Aim:Acute lung injury (ALI) is a life-threatening inflammatory syndrome that lacks an effective therapy. Dioscin, a natural steroid saponin isolated from a variety of herbs, could serve as an anti-inflammatory agent, as suggested in previous reports. The purpose of this study was to explore
Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice.
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Aim: Acute lung injury (ALI), a critical illness syndrome with high morbidity and mortality, is characterized by a severe inflammatory response. Dioscin exerts protective effects against crystalline silica-induced pulmonary inflammation and fibrosis in mice. Bleomycin (BLM) is widely used to
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