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diphenyl/infiammazione
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Pagina 1 a partire dal 26 risultati
1,5-diphenyl pyrazole compounds for treatment of inflammation
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FIELD OF THE INVENTION
This invention is in the field of anti-inflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating inflammation and inflammation-associated disorders, such as arthritis.
BACKGROUND OF THE INVENTION
Prostaglandins play a major
Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
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BACKGROUND OF THE INVENTION
This invention relates to methods of treating cyclooxygenase mediated diseases and certain pharmaceutical compositions therefor.
Non-steroidal, anti-inflammatory drugs exert most of their anti-inflammatory, analgesic and antipyretic activity and inhibit hormone-induced
Diphenyl ether derivatives
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FIELD OF THE INVENTION
The present invention relates to novel diphenyl ether derivatives of formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable
Heterocyclic diphenyl ethers
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FIELD OF THE INVENTION
The present invention relates to novel heterocyclic compounds of the general formula (I), derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof, and pharmaceutically
Heterocycle substituted diphenyl leukotriene antagonists
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BACKGROUND OF THE INVENTION
The metabolic routes in which various compounds are biosynthesized from arachidbnic acid, are collectively called the "Arachidonic Acid Cascade."
Leukotriene B.sub.4 (LTB.sub.4) is one of many products resulting from the arachidonic acid cascade.
Moreover, LTB.sub.4 in
Diphenyl-cyclopropenes as selective K-agonists
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BACKGROUND OF THE INVENTION
The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome, and stroke.
The compounds are K-agonists which
Diphenyl-cyclopropenes as selective K-agonists
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BACKGROUND OF THE INVENTION
The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome, and stroke.
The compounds are K-agonists which
Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives
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BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates to substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful as anti-inflammatory
Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues
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BACKGROUND OF THE INVENTION
The stilbenes isolated from Photorhabdus species bacteria are known to have antibiotic activity (Paul et al. Journal of Chemical Ecology, 7: 589-597 (1981), and Hu et al., Canadian Journal of Microbiology. 44: 1072-1077 (1998). However, these compounds have not been shown
1,5-diphenyl-penta-1,4-dien-3-one compounds
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BACKGROUND
Signal Transducer and Activator of Transcription (STAT) proteins are transcription factors that mediate cellular responses to growth factors. These proteins are activated via tyrosine phosphorylation by growth factor receptor-associated tyrosine kinases. Activated STAT proteins promote
Diphenyl heterocyclic thioamide derivatives
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BACKGROUND OF THE INVENTION
Vascular cell adhesion molecule-1 (VCAM-1), a member of the immunoglobulin (Ig) supergene family, is expressed on activated, but not resting, endothelium. The integrin VLA-4 (a.sub.4 b.sub.1), which is expressed on many cell types including circulating lymphocytes,
Diphenyl carbocyclic thioamide derivatives
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BACKGROUND OF THE INVENTION
Vascular cell adhesion molecule-1 (VCAM-1), a member of the immunoglobulin (Ig) supergene family, is expressed on activated, but not resting, endothelium. The integrin VL4 (a.sub.4 b.sub.1), which is expressed on many cell types including circulating lymphocytes,
4-6-diphenyl pyridine derivatives as antiinflammatory agents
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DETAILED DESCRIPTION OF INVENTION
1. Technical Field
The present invention relates to novel 4-aryl pyridine derivatives, processes for preparing them and pharmaceutical preparations containing them. The 4-aryl pyridine derivatives of the present invention inhibit I.kappa.B kinase .beta. (IKK-.beta.
Diphenyl compounds which inhibit arachidonic acid metabolism, and their use in pharmaceutical compositions
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The invention relates to pharmaceutical compositions containing liopxygenase- and prostaglandin H synthase-inhibiting active ingredients for preferably topical application in human and veterinary medicine. They are used in particular for the treatment of inflammatory skin diseases of non-microbial
Diphenyl substituted alkanes
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FIELD OF THE INVENTION
The instant invention involves compounds that inhibit 5-lipoxygenase activating protein (FLAP), compositions containing such compounds and methods of treatment using such compounds for the treatment and prevention of atherosclerosis and related diseases and
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