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gitoxin/hymenoxys rusbyi
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Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: I. Disposition kinetics following an i.v. bolus of 3H-gitoxin.
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Kinetics and metabolism of 3H-gitoxin were determined in the guinea-pig after the i.v. administration of 80 microgram gitoxin/kg. The time course of plasma concentration and urinary amounts remaining to be excreted were described according to the three-compartment linear body model. Apparent
A further study of the pharmacokinetics of gitoxin in rabbit isolated liver: clearance of 3H-gitoxin.
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Hepatic clearance of 3H-gitoxin was studied in the rabbit using an isolated perfused liver technique with an emulsion of a perfluorocarbon. The liposoluble material in the perfusion medium was extracted with dichloromethane, and gitoxin was assayed in the extract by high performance liquid
Hepatic clearance of gitoxin. Metabolism and biliary excretion by rabbit isolated liver.
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After in vitro perfusion of rabbit isolated liver with an emulsion of perfluorocarbon containing [3H]gitoxin, the radioactivity in the liver and in the bile was the sum of that contained in a volatile fraction (tritiated water due to metabolism of gitoxin) and that contained in a nonvolatile
Separation of digoxin, digitoxin and their potential metabolites, impurities or degradation products by high-performance liquid chromatography.
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A rapid and versatile series of high-performance liquid chromatographic systems are described for the resolution of digoxin, digitoxin and their potential metabolites or degradation products and impurities. These systems consist of isocratic, single-step gradient and linear gradient modes that
Multiresidue screen for cardiotoxins by two-dimensional thin-layer chromatography.
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A two-dimensional thin-layer chromatographic method was developed for the qualitative determination of the cardiotoxins oleandrin, gitoxin, digitoxin, gitoxigenin, and grayanotoxins I, II, and III in gastrointestinal contents (stomach, rumen, colon, and cecum contents), feces, and plant material.
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