All participants to receive study intervention.

Retinitis Pigmentosa

After completing the pretreatment visits, all patients will enter into the treatment phase where patients will receive 1800 mg of NAC effervescent tablets twice a day. The patients will be followed up every 3 months for 2 years. Therefore, there will be a total of 9 treatment visits (baseline, months 3, 6, 9, 12, 15, 18, 21 and 24).

NAC effervescent tablets

Wilmer Eye Institute at Johns Hopkins University

FIGHT-RP 1 Extension Study

A Phase 1 Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of N-Acetylcysteine (NAC) in Patients With Retinitis Pigmentosa

Blood pressure in mmHg will be used in assessing tolerability of N-Acetylcysteine.

Participants will be assessed for the occurrence of any drug-related symptoms which includes nausea, stomach upset, diarrhea, heartburn, constipation, and vomiting. Based on the number and severity of the symptoms, the physician would conclude whether the patient is tolerating the medication or not.

Medication diary provided to participants will be reviewed to see if participants are taking the medication within the designated time frame.

Medication diary provided to participants will be reviewed to see if participants are taking the medication twice a day

Scoring is determined by the number of letters gained or lost per month using Early Treatment Diabetic Retinopathy Study (ETDRS) Letter Score and visual acuity score together with an overall score range of 0 to 20/20 where 0 is the worst vision and 20/20 is the best.

Microperimetry (MAIA) is used to test whether there is an increase or decrease in sensitivity (dB) in the retina after initiation of N-Acetylcysteine

This will be assessed by spectral domain optical coherence tomography (SD-OCT) after initiation of N-Acetylcysteine.

This will be calculated from the proportions of reduced glutathione and oxidized glutathione in the aqueous.

Johns Hopkins University

Standard general anaesthesia and ventilation with FiO2 0.50 for at least 45 minutes following the standard settings in our department.

Exhaled breath condensate and arterial blood for matabolomic analysis.

Metabolomics

Anesthesia, General

Oxygen

Departmen of Anaesthesia and Intensive Care Medicine, Aalborg University Hospital

Metabolic and Physiological Changes During Minor Orthopaedic Surgery in Otherwise Healthy Patients

Metabolites measured by Nuclear Magnetic Resonance spectroscopy (NMR), explanatory study thus every changes in metabolites will be visualized

changes in the heart rate meassured 30 minutes after the awakening from general anaesthesia compaired to baseline (30 minutes before surgery)

changes in the oxygen saturation meassured 30 minutes after the awakening from general anaesthesia compaired to baseline (30 minutes before surgery)

Measured with blodgas analyzer (Radiometer, Denmark)

Bodil Steen Rasmussen

Professor

Aalborg University Hospital

Healthy Eating Index (HEI) in supervised pregnancies

women attending the obstetrics unit who did not follow a supervised diet

Dietary Habits

Dietetic treatment was calculated according to height, weeks of gestation and weight, considering an energy intake of 30 kcal/kg of expected weight, distributing the resulting energy according to the percentage of macronutrients' adequation (55-65% carbohydrates, 10-20% fat and the remainder as proteins).16 On each nutritional visit, 24 hour dietary recall was done and analyzed using NutriKcal®VO software in order to evaluate the Healthy Eating Index (HEI), which is commonly employed to assess pregnant women's dietary adequacy (on a scale from 0-100), through the consumption of 12 components of food groups described previously. An improvement in diet was considered when the initial HEI score improved more than one point during the next nutritional assessment.

Materno-Perinatal Hospital "Mónica Pretelini"

A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta

A Supervised Nutritional Program in Pregnancies Diminish the NF-κB Expression in Placenta

measure of gene expression by real time PCR

Hugo Mendieta Zeron

General Internal Medicine, Researcher

Materno-Perinatal Hospital of the State of Mexico

National Council of Science and Technology, Mexico

Secretariat of Public Education (SEP)

Nephropathy

Oxidative Stress

NS 500ml + Glutathione 1.8g intravenously guttae 1-1.5ml/kg per hour,30 minutes before and during coronary angiography

Glutathione

NS 500ml intravenously guttae 1-1.5ml/kg per hour,30 minutes before and during coronary angiography

saline

Department of cardiology and nephrology,Huashan Hospital

Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy

Polymorphism of Oxidative Stress Relative Genes in Contrast Medium Induced Nephropathy:Implications in the Pathogenesis and the Effect of Antioxidant prevention-a Prospective,Randomized,Controlled Study

CIN is defined as a relative increase of the serum creatinine by 25% or as an absolute increase of 0.5mg/dl(44.2umol/l) from baseline within 48-72h after contrast exposure.

glutathione/edema

FIGHT-RP 1 Extension Study

Metabolic and Physiological Changes During Minor Orthopaedic Surgery in Otherwise Healthy Patients

A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta

Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy

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