glycyrrhetinic acid/edema

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Inhibitory effect of glycyrrhetinic acid derivatives on capsaicin-induced ear edema in mice.

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We examined the effect of glycyrrhetinic acid (Ia) and its derivatives on ear edema induced by topical application of capsaicin in mice. Three dihemiphthalate compounds: di-sodium salt of 18 beta-olean-12-ene-3 beta,30-diol (deoxoglycyrrhetol, IIa) di-O-hemiphthalate (IIb); 18

Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo(a)pyrene.

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Glycyrrhetinic acid (GA) is an active component of Glycyrrhiza uraleusis fisch. In this study, GA was found to inhibit ear edema and ornithine decarboxylase (ODC) activity induced by croton oil in mice. GA could also protect rapid DNA damage and decrease the unscheduled DNA synthesis induced by

Trioxolone Methyl, a Novel Cyano Enone-Bearing 18βH-Glycyrrhetinic Acid Derivative, Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice

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Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid

[Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo (a) pyrene].

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Glycyrrhetinic acid (GA) is an active component of Glycyrrhiza uralensis Fisch. In this study, the effects of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo (alpha) pyrene were studied. Mouse ear edema was visible obviously at the 6th h after topical application of

Comparative studies of the stereoisomers of glycyrrhetinic acid on anti-inflammatory activities.

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Anti-inflammatory activity of the stereoisomers, 18 alpha and 18 beta-glycyrrhetinic acid (18 alpha and 18 beta-GA), obtained from Glycyrrhizae Radix, was investigated by using carrageenan-induced edema in mice and 18 alpha-GA was found to be more active than 18 beta-GA. Therefore, to clarify the

Synthesis, anti-microbial and anti-inflammatory activities of 18β-glycyrrhetinic acid derivatives

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Thirteen 18β-glycyrrhetinic acid (GA) derivatives were obtained by reduction at C-11 position, oxidation at C-3 position and condensation at C-2 position of GA. Anti-microbial activity evaluation indicated that compounds 04, 05, 10, 13 and 14 showed more potent inhibitory activity against

Anti-inflammatory and anti-nociceptive activity of disodium glycyrrhetinic acid hemiphthalate.

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The anti-inflammatory and anti-nociceptive effects of disodium glycyrrhetinic acid hemiphthalate (glycyrrhetinic acid 3 beta-O-hemiphthalate sodium) after parenteral administration were determined in several animal models. Disodium glycyrrhetinic acid hemiphthalate (GAP) significantly inhibited the

[Novel Glycyrrhetinic Acid Derivative Soloxolone Methyl Inhibits the Inflammatory Response and Tumor Growth in vivo].

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Due to wide spreading of inflammatory disease and imperfection of available anti-inflammatory drugs, mainly associated with their serious side effects, searching for new anti-inflammatory agents is a pressing problem. Natural triterpenoids and their synthetic analogs are a promising source of new

Glycyrrhetinic acid alleviates acute lung injury by PI3K/AKT suppressing macrophagic Nlrp3 inflammasome activation

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Glycyrrhetinic acid (GA), a triterpene saponins, has been widely proven to have multiple medicinal properties. Our study aimed to figure out the protective effect of GA on acute lung injury (ALI) and the underlying mechanism. The LPS-induced ALI model mice were intratracheally administrated with 10

High renin low blood pressure and its treatment with calcium glycyrrhetinyl-glycinate.

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Elevated plasma renin activity was found in 6 out of 7 essential hypotensive patients. This was taken to reflect some abnormality in sodium handling, and they were treated with synthetic calcium glycyrrhetinyl-glycinate (G.G.), a water soluble derivative of glycyrrhetinic acid which was derived from

[Severe hypokalemia after holidays return].

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A 52-year old man is referred to our institution for hypertension (190/90 mmHg) and lower limb edema. An initial blood sample reveals severe hypokalemia (1.58 mEq/l) associated with metabolic alkalosis (pH: 7.63; total bicarbonates: 47.7 mEq/I), rhabdomyolysis (CPK: 1.776 UI/I) and ECG

Research and development of cancer chemopreventive agents in China.

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Since the late 1970s, a comprehensive search for cancer chemopreventive agents has been established in our Institute. A series of new retinoids have been synthesized and screened on the basis of established methodologies of experimental chemoprevention in vitro as well as in vivo. Pharmacological

Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study.

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Partial necrosis of skin flaps continues to restrict the survival of local skin flaps following plastic and reconstructive surgeries. The aim of the present study was to investigate the effects of diammonium glycyrrhizinate (DG), a salt of glycyrrhetinic acid that has been widely used in the therapy

Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root.

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OBJECTIVE Licorice has been shown to possess cancer chemopreventive effects. However, glycyrrhizin, a major component in licorice, was found to interfere with steroid metabolism and cause edema and hypertension. The roasting process of licorice modifies the chemical composition and converts

Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor.

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Despite the usefulness of glucocorticoids, they may cause hazardous side effects that limit their use. Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone,

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