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Age-related increase of reactive oxygen generation in the brains of mammals and birds: is reactive oxygen a signaling molecule to determine the aging process and life span?
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Since Harman proposed the "free-radical theory of aging", oxidative stress has been postulated to be a major causal factor of senescence. The accumulation of oxidative stress-induced oxidatively modified macromolecules, including protein, DNA and lipid, were found in tissues during the aging
[Analysis of aging-related oxidative stress status in normal aging animals and development of anti-aging interventions].
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Since Harman proposed the "free-radical theory of aging", oxidative stress is postulated to be a major causal factor of senescence. Accumulation of oxidative stress-induced oxidatively modified macromolecules including protein, DNA, and lipid, were found in tissues during the aging process. However,
Preservation of Neurovascular Coupling to Cognitive Activity in Anterior Cerebrovasculature During Incremental Ascent to High Altitude.
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Lefferts, Wesley K., Jacob P. DeBlois, Jan Elaine Soriano, Leah Mann, Zahrah Rampuri, Brittney Herrington, Scott Thrall, Jordan Bird, Taylor S. Harman, Trevor A. Day, Kevin S. Heffernan, and Tom D. Brutsaert. Preservation of neurovascular coupling to cognitive activity in anterior cerebrovasculature
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