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Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation.
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Lipid peroxidation of docosahexaenoic (22:6; n-3) acid (DHA) is elevated in the CNS in patients with Alzheimer's disease and in animal models of seizure and ethanol withdrawal. One product of DHA oxidation is trans-4-hydroxy-2-hexenal (HHE), a six carbon analog of the n-6 fatty acid derived
[Advantages of using pharmacologic tests to characterize bacterial vaccines].
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The possibility of using pharmacological tests to determine side effects produced by adsorbed DPT vaccine and chemical typhoid vaccine was studied. Both vaccines were shown to be capable of prolonging sleep induced by hexenal or thiopental in experimental animals. The following difference in the
[Lithium valproate: its neuropharmacological spectrum and effect on transmitter amino acid content of the brain of rats].
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The authors studied lithium valproate synthesized at the Institute of Pharmacology, Academy of Medical Sciences of the USSR, and compared it with sodium valproate (depakin, France). It was discovered that like sodium valproate, lithium valproate has a marked anticonvulsant activity, being also
[Pharmacology of uxepam].
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A new daytime tranquilizer uxepam--1-methyl-4-carbamoyl-5-phenyl-7-chloro-1,3,4,5-tetrahydro-2H-1, 4-benzodiazepine-2-on (RGH-3331) administered to animals removes emotional-behavioral abnormalities under conflict situation, reduces aggressiveness induced by electric and painful stimulation,
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