A chlorhexidine gluconate occlusive adhesive dressing (Tegaderm CHG) will be applied to the intervention drain sites and changed every seven days.

Standard drain care will be performed twice a day or three times if bulb is full and needs to be emptied. Standard drain care consists of stripping the tubing, emptying the drainage bulb, recording the volume of fluid, and cleaning the drain site and the tubing with a cotton swab dipped in rubbing alcohol.

Breast Cancer

Antiseptic occlusive dressing group

Instituto Nacional de Cancerología

Use of Clorhexidine Dressings to Reduce Surgical Site Infections in Breast Cancer Surgery. A Controlled Clinical Trial

Randomized Controlled Trial to Reduce Surgical Site Infections in Breast Cancer Surgery With Clorhexidine Gluconate Securement Dressing (Tegaderm CHG)

Bacterial growth was defined as plate growth >10*5 colony forming unit (CFU). Drains were removed at variable times across patients, per clinical indication. When clinically indicated, some patients did have their drains removed at the one week visit, in which case they only had one bulb fluid culture.

Bacterial growth was defined as plate growth >15 CFU by semiquantitative technique or >10*5 CFU by sonication and fluid culture. Drains were removed at variable times across patients, per clinical indication.

Surgical site infection was diagnosed according the definitions given by the Centers for Disease Control and Prevention (CDC).

MYRNA CANDELARIA, MD PHD

Ethics Commissioner

National Institute of Cancerología

Instituto Nacional de Rehabilitacion

Patients randomised to receive pectoral plane blocks and a sham local anaesthetic infusion wound catheter

Patients randomised to receive a local anaesthetic infusion wound catheter; No sham pectoral plane block performed as patients usually under general anaesthetic at time of block.

Patients randomised to receive pectoral plane blocks and a local anaesthetic infusion wound catheter.

Breast Diseases

Anesthesia

Block

Pectoral Plane Block

Levobupivicaine 0.1% @10ml/hr via a wound infusion catheter

Local Anaesthetic Wound Infusion Catheter

Department of Anaesthesia, Mater Misericordiae University Hospital

Single-shot Pectoral Plane(PECs) Block Versus Continuous Local Anaesthetic Infusion Analgesia or Both PECS Block and Local Anaesthetic Infusion After Breast Surgery: A Prospective Randomised, Double-blind Trial

Single-shot Pectoral Plane (PECs) Blocks Versus Continuous Local Anaesthetic Infusion Analgesia or Both PECs Block and Local Anaesthetic Infusion After Non-ambulatory Breast Cancer Surgery: A Prospective, Randomised, Double-blind Trial

IPD will not be made available to other researchers as this has been pre-determined with patients as part of the process of informed consent.

Sean Keane

Dr. Sean Keane; Anaesthesia SpR

Mater Misericordiae University Hospital

Preoperative skin preparation with chlorhexidine 2% in alcohol 70% solution

Preoperative skin preparation with povidone-iodine 10% solution

Wound Infection

Breast Neoplasms

Preoperative skin preparation with tinted chlorhexidine gluconate 2% in 70% isopropyl alcohol administered with single-dose applicator

Chlorhexidine

Preoperative skin preparation with povidone-iodine 10% aqueous solution

Povidone-Iodine

Fondazione IRCCS Istituto Nazionale dei Tumori

Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine

A Randomized, Blinded, Single Center Study to Assess the Incidence of Surgical Site Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine 2% in Alcohol 70% (CHLORAPREP ®) Versus 10% Povidone-iodine

Overall incidence of surgical site infections after surgery

Multivariate analysis of risk factors: presence or absence of implant, previous chemotherapy treatment, previous radiotherapy treatment, American Society Association class > 2, length of surgery > 2 hours, body mass index > 35, diabetes mellitus

Record of number of additional hospital admission, length of stay, need of additional surgery, days of additional antibiotic therapy, delay of anticancer therapy due to wound infection

Cost-effective analysis if one treatment proves significantly superior to the other

isopropyl alcohol/tumore della mammella

Use of Clorhexidine Dressings to Reduce Surgical Site Infections in Breast Cancer Surgery. A Controlled Clinical Trial

Single-shot Pectoral Plane(PECs) Block Versus Continuous Local Anaesthetic Infusion Analgesia or Both PECS Block and Local Anaesthetic Infusion After Breast Surgery: A Prospective Randomised, Double-blind Trial

Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine

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