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l norepinephrine/ischemia
Il collegamento viene salvato negli appunti
8 risultati
Effects of ischemia on discontinuous action potential conduction in hybrid pairs of ventricular cells.
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BACKGROUND
Acute ischemia often occurs in cardiac tissue that has prior injury, resulting in spatially inhomogeneous distributions of membrane properties and intercellular coupling. Changes in action potential conduction with ischemia, which can be associated with release of catecholamines, may be
Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway.
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During myocardial ischaemia the beta-adrenoceptor is activated, which contributes, at least partly, to cardiac arrhythmias via inducing [Ca2+]i oscillations. Since beta-adrenoceptor is negatively modulated by the kappa-opioid receptor in the heart, the present study attempted to determine if
Antiarrhythmic activity of flestolol, a novel ultra-short-acting beta-adrenoceptor antagonist, in the dog.
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The antiarrhythmic activity of flestolol, an ultra-short acting beta-adrenergic blocker lacking appreciable local anesthetic activity, was examined in several different canine ventricular arrhythmia models. Flestolol, at steady state infusions of 1-1,000 micrograms/kg per min, was generally
Diazoxide provides protection to human myocardium in vitro that is concentration dependent.
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BACKGROUND
Diazoxide has been shown to confer significant myocardial protection in many experiments. This study was designed to assess its influence on the structural injury and functional recovery of human myocardium subjected to hypoxia/reoxygenation in vitro.
METHODS
The isolated electrically
Catecholamines and preconditioning: studies of contraction and function in isolated rat hearts.
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The aims of this study were to determine whether 1) like ischemic preconditioning, transient exposure to norepinephrine before ischemia exacerbates contracture during ischemia and 2) protection afforded by norepinephrine is stereospecific (receptor mediated). Isolated perfused rat hearts were
The relation of angiotonin and 1-norepinephrine to essential hypertension as determinded by the reaction of the nailfold capillary bed.
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Further evidence has been obtained that L-norepinephrine infusions markedly decreases cutaneous capillary blood flow in the nailfold. Sustained ischemia of the capillary bed occurred prior to the attainment of hypertensive diastolic arterial blood pressure levels. Corroborative evidence of this
Use of catecholamines in acute myocardial infarction.
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We review the hemodynamic effects and clinical usefulness of five natural and synthetic catecholamines. Their actions are best understood by an appreciation of the relative ability of each catecholamine to activate alpha, beta 1 and beta 2 adrenergic receptors in the myocardium and peripheral
Coronary artery spasm induced by intravenous epinephrine overdose.
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A 27-year-old man was accidentally given 2 mg intravenous epinephrine instead of 2 mg naloxone. He immediately developed chest pain, nausea, and diaphoresis. An ECG taken shortly after the epinephrine administration showed widespread ischemia. Forty-five minutes later the tracing still showed an
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