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Lobeline produces conditioned taste avoidance in rats.
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Previous results indicate that pretreatment with lobeline attenuates methamphetamine (METH) self-administration in rats, but not by acting as a substitute reinforcer. Given these findings, it has been suggested that lobeline may serve as a useful pharmacotherapy for psychostimulant abuse. However,
Methamphetamine-like discriminative-stimulus effects of nicotinic agonists.
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Nicotine was recently shown to engender d-methamphetamine (MA)-like discriminative-stimulus effects in rats, which may be indicative of shared psychomotor stimulant properties. To further investigate such overlapping discriminative-stimulus effects, nicotinic agonists varying in efficacy and
Studies on vomitory effect of some acridine compounds.
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Vomitory effect of 16 chosen acridine derivatives was observed on pigeons. The expected effect of the preparations as well as their interaction with, causing vomiting lobeline were considered. Two groups were distinguished: 1) preparations which alone caused vomitory reaction (C-283, C-410, C-541,
Emetic reflex arc revealed by expression of the immediate-early gene c-fos in the cat.
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The organization of the central neuronal circuitry that produces vomiting was explored by mapping the distribution of c-fos protein (Fos)-like immunoreactivity (FLI) as a monitor of functional activity. The brainstem and spinal cord were examined in cats administered multiple emetic drugs
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