lycoctonine/aconitum

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New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors.

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Two new diterpenoid alkaloids, heterophyllinine-A (1) and heterophyllinine-B (2), along with two known alkaloids dihydroatisine (3) and lycoctonine (4) were isolated from the roots of Aconitum heterophyllum Wall. The structure of (1) and (2), were deduced on the basis of spectral data. Compounds 1-2

Isolation of norditerpenoid alkaloids from flowers of aconitum lycoctonum

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The structures of two new lycoctonine-type alkaloids having an acetoxy group at C-6, 6-O-acetyldemethylenedelcorine (1) and 6-O-acetyl-14-O-methyldelphinifoline (2), isolated from the flowers of Aconitum lycoctonum, were determined by spectroscopic analysis. In addition, 14-O-methyldelphinifoline

Diterpenoid alkaloids of Aconitum vulparia Rchb.

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From the roots of Aconitum vulparia Rchb., collected in Prüm (Germany), a new norditerpenoid alkaloid, named alexhumboldtine, has been isolated along with the known norditerpenoid alkaloids lappaconitine, anthranoyllycoctonine, lycoctonine, puberaconitine, ajacine, and septentriodine. The structure

[Diterpenoid alkaloids from Aconitum bulleyanum Diels].

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OBJECTIVE To investigate the diterpenoid alkaloids from Aconitum bulleyanum. METHODS Diterpenoid alkaloids were separated by solvent extraction and chromatography on silical gel, and their structures were determined by spectral analysis and chemical evidence. RESULTS Five diterpenoid alkaloids were

New C19-diterpenoid alkaloids from Aconitum hemsleyanum var leueanthus and Delphinium potaninii.

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A new franchetine-type (leueandine 1) and two new lycoctonine-type [potanisines F (3) and G (5)] C19-diterpenoid alkaloids have been isolated from the roots of Aconitum hemsleyanum var. leueanthus and Delphinium potaninii, respectively, and their structures were established on the basis of spectral

Alkaloids of Aconitum laeve and their anti-inflammatory antioxidant and tyrosinase inhibition activities.

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A lycoctonine-type norditerpenoid alkaloid, swatinine (1), along with four known norditerpenoid alkaloids, delphatine (3), lappaconitine (4), puberanine (5), and N-acetylsepaconitine (6), and were isolated from the aerial parts of Aconitum laeve Royle. Compound 2 has been isolated for the first time

Selective dual cholinesterase inhibitors from Aconitum laeve.

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New lycoctonine-type dual cholinesterase inhibitor, swatinine-C (1), along with three known norditerpenoid alkaloids, hohenackerine (2), aconorine (5) and lappaconitine (6) and two synthetically known but phytochemically new benzene derivatives, methyl 2-acetamidobenzoate (3) and methyl

8β-Acet-oxy-14α-benzo-yloxy-N-ethyl-3α,10β,13β,15α-tetra-hydr-oxy-1α,6α,16β-trimeth-oxy-4β-(methoxy-methyl-ene)aconitane: aconifine from Aconitum karakolicum Rapaics.

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The title compound, C(34)H(47)NO(12), is the norditerpenoid alkaloid aconifine isolated from the leaves and tubers of Aconitum karakolicum Rapaics. It has a lycoctonine carbon skeleton and contains four six-membered rings and two five-membered rings; its geometry is similar to that observed in other

Diterpene alkaloids from the roots of Aconitum moldavicum and assessment of Nav 1.2 sodium channel activity of aconitum alkaloids.

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A new aconitane alkaloid, 1-O-demethylswatinine (1), was isolated from the root of Aconitum moldavicum together with the known compounds cammaconine (2), columbianine (3), swatinine (4), gigactonine (5), delcosine (6), lycoctonine (7), and ajacine (8). The structures were established by means of

Norditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity.

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Two new aconitine-type norditerpenoid alkaloids 6-dehydroacetylsepaconitine (1) and 13-hydroxylappaconitine (2), along with three known norditerpenoid alkaloids lycoctonine, delphatine and lappaconitine were isolated from the roots of the Aconitum heterophyllum Wall. These compounds exhibited

Aconitum and Delphinium alkaloids of curare-like activity. QSAR analysis and molecular docking of alkaloids into AChBP.

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Early studies have shown that some of diterpenoid alkaloids, found in highly toxic plants of the genera Aconitum and Delphinium, act at neuronal nicotinic acetylcholine receptors (nAChRs) and exhibit potent N-cholinolytic activity. In the current study, GA-MLRA and GA-PLS approaches have been used

[Investigation of the diterpene alkaloids of Aconitum species native to the Carpathian Basin].

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Aconitum species accumulate highly toxic diterpene alkaloids, which have attracted considerable interest because of their complex structure, interesting chemistry and noteworthy physiological effects. The authors carried out phytochemical analysis of two Aconitum species native to the Carpathian

Norditerpenoid alkaloids from the roots of Aconitum leave Royle.

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From the roots of Aconitum leave Royle growing wild in Northern Pakistan, Swat district, three new alkaloids, 8-methyllycaconitine (1), 14-demethyllycaconitine (2), N-deethyllycaconitine-N-aldehyde (3) have been isolated along with four known compounds, lappaconitine (4), lycaconitine (5),

Mode of antinociceptive and toxic action of alkaloids of Aconitum spec..

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Extracts of the plant Aconitum spec. are used in traditional Chinese medicine predominantly as anti-inflammatory and analgesic agents, the latter allegedly equally potent as morphine but without any habit-forming potential. As the only pharmacologically active compounds, the C19 diterpenoid alkaloid

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