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Pagina 1 a partire dal 17 risultati
Mechanisms of napelline action stimulating the regeneration of hemopoietic tissue in cytostatic myelosuppression.
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Pronounced regenerative effects of alkaloid napelline extracted from Aconitum baicalense on granulocytic hemopoiesis were revealed in the model of cytostatic myelosuppression. Activation of functions of hemopoietic progenitor cells along with increased feeder capacity of the stromal elements in the
Inhibition of rat hippocampal excitability by the Aconitum alkaloid, 1-benzoylnapelline, but not by napelline.
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The effects of the two structurally related Aconitum alkaloids, 1-benzoylnapelline and napelline, were investigated by extracellular recording of the stimulus-evoked population spike in the CA1 region of rat hippocampal slices in vitro. 1-Benzoylnapelline (1-100 microM) exerted a depressant action
Fifteen new diterpenoid alkaloids from the roots of Aconitum kirinense Nakai.
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Extensive phytochemical investigation from the roots of Aconitum kirinense Nakai led to the identification of fifteen new compounds, including four ranaconitine type C18-diterpenoid alkaloids (kirisines A-D, 1-4), one lappaconitine type C18-diterpenoid alkaloid (kirisine E, 5),
Alkaloidal constituents from Aconitum jaluense.
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Aconitum jaluense Komar. (Ranunculaceae) is one of the Aconitum plants growing in Korean peninsula. An investigation of the alkaloidal constituents of this species led to the isolation of seven C19-norditerpenoid and a C20-diterpenoid alkaloid. Three of them have been identified as neoline,
Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch.
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Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1-3, two aconitine-type diterpenoid alkaloids 4-5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Compounds 1
Diterpenoid Alkaloids from Aconitum soongaricum var. pubescens.
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One new diterpenoid alkaloid, pubescensine (1), along with nine known diterpenoid alkaloids (2-10) were isolated from the roots of Aconitum soongaricum var. pubescens. Their structures were elucidated by spectroscopic analyses and comparison with previously reported data. All the compounds were
A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang.
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A new denudatine-type C20-diterpenoid alkaloid, designated as sinchianine (1), together with eight known diterpenoid alkaloids, 12-acetyl-12-epi-napelline (2), 12-epi-napelline (3), neoline (4), talatisamine (5), 14-O-acetylsenbusine A (6) and benzoylaconine (7), songorine (8) and aconitine (9),
Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids.
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Diterpene alkaloids neoline (1), napelline (2), isotalatizidine (3), karakoline (4), senbusine A (5), senbusine C (6), aconitine (7) and taurenine (8) were identified from Aconitum napellus L. subsp. firmum, four (2-4, 6) of which are reported for the first time from this plant. The structures were
Structures of Flavamine and Flavadine from Aconitum flavum.
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Two new diterpenoid alkaloids, flavamine ( 1) and flavadine ( 2), were isolated from the roots of ACONITUM FLAVUM Hand-Mazz. The structures were established on the bases of spectral analyses and chemical correlations with napelline ( 3) and lucidusculine ( 4), respectively.
Three new diterpene alkaloids from the roots of Aconitum nagarum var. lasiandrum.
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Three new diterpene alkaloids, 16,17-dihydro-12 beta,16 beta-epoxynapelline (1), N-deethyl- N-methyl-12-epi-napelline (2) and 11- epi-16 alpha,17-dihydroxylepenine (3), along with twenty-six known alkaloids (4 - 29) were isolated from the roots of Aconitum nagarum var. lasiandrum. The chemical
Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum.
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Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties. Aconitum is a genus rich of diverse
Analgesic activity of diterpene alkaloids from Aconitum baikalensis.
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We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were
[Investigation of the diterpene alkaloids of Aconitum species native to the Carpathian Basin].
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Aconitum species accumulate highly toxic diterpene alkaloids, which have attracted considerable interest because of their complex structure, interesting chemistry and noteworthy physiological effects. The authors carried out phytochemical analysis of two Aconitum species native to the Carpathian
Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense.
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We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity
Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense.
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The effects of complex extract from Aconitum baikalense on reparative regeneration of a plane dorsal skin wound were studied. Treatment with Aconitum baikalense tincture stimulated reparation and skin regeneration. The effects of the Aconitum baikalense alkaloids on functional activity of fibroblast
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