Aim 1: Twice-daily ingestion of 20 g of EAA for 1 wk before through 6 wk after TKA.
Supplement composition for the EAAs: histidine, 2.2 g (11% of total); isoleucine, 2.0 g (10%); leucine, 3.6 g (18%); lysine, 3.2 g (16%); methionine, 0.6 g (3%); phenylalanine, 3.2 g (16%); threonine, 2.8 g (14%); and valine, 2.4 g (12%).
Aim 2: Twice-daily ingestion of 23 g of EAA for 1 wk before through 6 wk after TKA.
Supplement composition for the EAAs: histidine, 1.28 g (5% of total); isoleucine, 1.8 g (8%); leucine, 7.4 g (32%); lysine, 3.6 g (15%); methionine, 1.76 g (8%); phenylalanine, 3.1 g (13%); threonine, 1.9 g (8%); valine, 2.08 g (9%); and tryptophan, 0.5 g (2%).

Aim 1: Twice-daily ingestion of 20 g of Alanine (Non-essential amino acid) for 1 wk before through 6 wk after TKA.
The placebo supplement consists of 20 g (100%) alanine.
Aim 2: Twice-daily ingestion of 23 g of Alanine (Non-essential amino acid) for 1 wk before through 6 wk after TKA.
The placebo supplement consists of 23 g (100%) alanine.

Muscle Atrophy

Quality of Life

Twice daily ingestion of 20 or 23 grams of EAA for 7 days leading up to surgery and continuing for 6 weeks after surgery [surgery = primary total knee arthroplasty]

Essential Amino Acids (EAA)

Twice daily ingestion of 20 or 23 grams Placebo (alanine) for 7 days leading up to surgery and continuing for 6 weeks after surgery [surgery = primary total knee arthroplasty]

Placebo (Alanine)

Muscle Physiology Lab at the University of Oregon

University of Oregon

Slocum Center for Orthopedics and Sports Medicine

Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults

We will measure volumetric muscle volume using MRI

We will measure the change in the distance covered in 6 minutes (6 minute walk test)

We will measure the change in timed stair descent

We will measure the change in timed stair ascent

We will measure the change in timed Get Up and Go

Hans Dreyer

Assistant Professor

Slocum Research & Education Foundation

Oregon Research Institute

Oregon Health and Science University

University of Arkansas

National Institute on Aging (NIA)

Retinal Degeneration

Retinitis Pigmentosa

National Institutes of Health Clinical Center, 9000 Rockville Pike

Harvard Medical School

Cleveland Clinic Foundation Childrens Hospital

Sun Yat-Sen University

Aravind Eye Hospital

University of Punjab

Molecular Genetics of Retinal Degenerations

National Eye Institute (NEI)

Scheduled for an in-patient, elective spine surgery where subject will receive general anesthesia

Presenting to spine clinic and undergoing conservative, non-surgical management of spine disorder

Blood samples will be obtained for DNA extraction and storage. Genotyping will be done in batches. Genotyping will be performed using the polymerase chain reaction (PCR) method, and the specific genes of interest include apolipoprotein E (APOE) and phospholipase A (PLA).

Cognitive Decline

OHSU

Cohort Study of Risk Factors for Postoperative Cognitive Decline

To determine whether specific genetic variables (i.e. APOE4 or PLA2 alleles) and/or biological sex confer a higher risk to developing postoperative cognitive and functional status decline in older adults.

oregon/atrofia

Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults

Molecular Genetics of Retinal Degenerations

Cohort Study of Risk Factors for Postoperative Cognitive Decline

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