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picrinine/alstonia scholaris
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13 risultati
Alstonic acids A and B, unusual 2,3-secofernane triterpenoids from Alstonia scholaris.
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2,3-Secofernane triterpenoids, alstonic acids A (1) and B (2), were isolated from the leaves of Alstonia scholaris together with an indole alkaloid, N(1)-methoxymethyl picrinine (3). Their structures were established from MS and NMR spectroscopic analyses and confirmed by single crystal X-ray
Fischer Indolizations as a Strategic Platform for the Total Synthesis of Picrinine.
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Picrinine, which is a member of the akuammiline family of alkaloids, was first isolated in 1965 from the leaves of Alstonia scholaris. The natural product possesses a daunting polycyclic skeleton that contains a furanoindoline, a bridged [3.3.1]azabicycle, two N,O-acetal linkages, and six
A new indole alkaloid from Alstonia scholaris.
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A new indole alkaloid, N-formylscholarine, together with picrinine, strictamine and nareline has been isolated from the fruit pods of Alstonia scholaris, and their structures were established by various spectral data. This is the first report of these alkaloids in A. scholaris fruit pods.
Alistonitrine A, a caged monoterpene indole alkaloid from Alstonia scholaris.
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Alistonitrine A, a new monoterpene indole alkaloid incorporating a third nitrogen atom, was isolated from the leaves of Alstonia scholaris and found to possess an unprecedented caged skeleton with a unique 6/5/6/5/5/6 ring system. Its structure and absolute configuration were established by
Characterization of chemical constituents and rats metabolites of an alkaloidal extract of Alstonia scholaris leaves by liquid chromatography coupled with mass spectrometry.
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Alstonia scholaris has been used in "Dai" ethnic medicine to treat chronic respiratory diseases for a long history, and the major bioactive constituents are alkaloids. An alkaloidal extract of A. scholaris leaves (AAS) has been developed into an investigational new drug, and has been approved for
[Application of FTIR and Active Ingredients Quantitative Analysis on Quality Control of Dai Medicine Alstonia scholaris (L.) R. Br.].
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FTIR fingerprint of the leaves and immature stems of Alstonia scholaris (L.) R. Br. was established as a content determination method for the detection of picrinine, ursolic acid and oleanolic acid. Different medicinal parts were identified based on principal component analysis, while exploring the
A cage-monoterpene indole alkaloid from Alstonia scholaris.
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An unprecedented cage-like alkaloid, scholarisine A was isolated from the leaves of Alstonia scholaris and its structure determined on the basis of 1D and 2D NMR, FTIR, UV, and high-resolution mass spectroscopic data. This alkaloid might be derived from picrinine via oxygenation, rearrangement, and
Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone.
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Three new monoterpenoid indole alkaloids, named normavacurine-21-one (1), 5-hydroxy-19, 20-E-alschomine (2), and 5-hydroxy-19, 20-Z-alschomine (3), together with thirteen known indole alkaloids (4-16) were isolated from the leaves of Alstonia scholaris cultivated in Kunming. Their structures were
Indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. protect against emphysema in mice.
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Pharmacological evaluation of Alstonia scholaris: anti-inflammatory and analgesic effects.
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BACKGROUND
Alstonia scholaris (Apocynaceae) has been historically used in "dai" ethnopharmacy to treat chronic respiratory diseases. The leaf extract, developed as a commercially available traditional Chinese medicine, used to release tracheitis and cold symptom, has also been prescribed in
Pharmacokinetics and safety evaluation in healthy Chinese volunteers of alkaloids from leaf of Alstonia scholaris: A multiple doses phase I clinical trial.
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Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice.
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BACKGROUND
Leaf of Alstonia scholaris (L.) R. Br. (Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also been recorded as the common traditional Chinese medicine for treatment of illnesses in respiratory system by Dai people.
OBJECTIVE
To provide experimental data of
Pharmacological evaluation of Alstonia scholaris: anti-tussive, anti-asthmatic and expectorant activities.
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BACKGROUND
Alstonia scholaris (Apocynaceae) was documented as an effective herb for the treatment of chronic respiratory diseases in "dai" ethnopharmacy historically, and its leaf crude extract, used for releasing tracheitis and cold symptom, was approved to be a commercial formulation by State Food
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