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pristimerin/celastrus
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Ultrasound-Assisted Extraction of Pristimerin from Celastrus orbiculatus Using Response Surface Methodology.
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This paper describes the ultrasound-assisted extraction (UAE) of pristimerin from Celastrus orbiculatus. Methanol was the most effective for pristimerin extraction, followed by ethanol, ethyl acetate, n-butanol, and water. To optimize the conditions, the Box-Behnken design, a widely used form of
Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus.
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Pristimerin and celastrol isolated from the roots of Celastrus hypoleucus (Oliv) Warb f argutior Loes exhibited inhibitory effects against diverse phytopathogenic fungi. Pristimerin and celastrol were found to inhibit the mycelial growth of Rhizoctonia solani Kuhn and Glomerella cingulata (Stonem)
[Chemical constituents of roots of Celastrus orbiculatus].
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OBJECTIVE
To study the chemical constitutes of roots of Celastrus orbiculatus.
METHODS
The compounds were isolated by column chromatography and identified by spectroscopic methods including IR, MS and NMR.
RESULTS
Nine compounds were isolated and identified as sugiol (1), friedelane-3-one (2),
Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer.
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Although angiogenesis inhibitors targeting VEGF/VEGFR2 have been applied for tumor therapy, the outcomes are still unsatisfactory. Thus, it is urgent to develop novel angiogenesis inhibitor for cancer therapy from new perspectives. Identification of novel angiogenesis inhibitor from natural products
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